Sunday, 21 February 2010

'Diabetic effect' in dolphins offers new hope for type 2 diabetes cure

February 20, 2010

'Diabetic effect' in dolphins

offers new hope for

type 2 diabetes cure

Dolphins

(Al Stanzani)

Dolphins also develop type 2 diabetes but can switch their insulin resistance on and off

Dolphins are the only animals apart from humans to develop a natural form of type 2 diabetes, according to new research. The discovery offers important insights into a disease that is linked to one in 20 deaths.

American scientists have discovered that bottlenosed dolphins show a form of insulin resistance very similar to that seen in human diabetes. Unlike patients with the condition, the marine mammals can turn this state on and off when appropriate, so it is not normally harmful.

The findings indicate that dolphins could provide a valuable animal model for investigating type 2 diabetes, which promises to advance research into new therapies. If researchers can learn how the animals switch off their insulin resistance before it becomes damaging, it could be possible to develop a cure.

Stephanie Venn-Watson, a veterinary epidemiologist at the US National Marine Mammal Foundation, who led the research, said that it could have profound implications for a disease that affects an estimated 2.75 million adults in Britain.

It suggests that the bottle-nosed dolphin is “an important, natural and long-lived model for insulin resistance and diabetes, a disease that accounts for 5 per cent of human deaths globally”, she told the San Diego conference of the American Association for the Advancement of Science. “It is our hope that this discovery can lead to novel ways to prevent, treat and even cure diabetes in humans while also benefiting dolphin health.”

She emphasised that the research did not mean that dolphins should be used as laboratory animals, as their large brains and high intelligence would make this unethical. Studies of their genetic code and physiology, revealed by blood and urine samples, could nevertheless provide important clues to the biology of diabetes.

The unexpected discovery has emerged from a study of more than 1,000 blood samples collected from 52 dolphins. When the animals had fasted overnight, their blood sugar remained high and their blood chemistry changed in ways similar to diabetic patients. Unlike people with diabetes, the dolphins’ blood reverted to normal once they had been fed.

Dr Venn-Watson said that such controlled diabetes might be beneficial to dolphins. Their diet of fish is high in protein and low in sugar, and they often go long periods without eating, yet they have large brains with high energy demands.

By making their bodies resistant to insulin while fasting, they may be able to keep their brains well supplied with sugar. Once they have eaten, the insulin resistance stops to prevent damage to their health. “We propose that, while some people may eat high- protein diets to help control diabetes, dolphins appear to have developed a diabetes-like state to support a high-protein diet,” she said. “It works to their advantage to have a condition that keeps blood sugar in the body.

“If dolphins indeed have a genetic fasting switch that can turn diabetes on and off, then finding and controlling such a switch could lead to the control of insulin resistance and possibly the cure to type 2 diabetes in humans.”

Dr Venn-Watson’s team has found that dolphins with excessive iron levels, or haemochromatosis, have high insulin levels that suggest a more harmful form of diabetes similar to the human disease. High iron is associated with insulin resistance in humans.

The findings are significant because there is no ideal animal model of type 2 diabetes. While rodents, cats, pigs and some primates display some aspects of diabetes, none mimics the disease as closely as dolphins.

Mark Simmonds, international head of science at the Whale and Dolphin Conservation Society, said there were ethical objections to using dolphins to study human disease and that dolphins were too distantly related from humans to be useful. He said: “The idea that dolphins would generally be a good model for the study of human disease seems unlikely. It is a grave concern that dolphins might be used in biomedical research. Dolphins are intelligent and sophisticated animals, vulnerable to stress and suffering when confined and removed from their natural environment.”

A link with obesity

• Type 2 diabetes occurs when the body acquires resistance to insulin — a hormone that controls blood sugar

• It is often triggered by obesity, though genetic factors are also involved, and it generally occurs in people over the age of 40

• The disease causes blood-sugar levels to become elevated, resulting in progressive damage to blood vessels and nerves

• Complications include cardiovascular disease, poor circulation leading to amputation of limbs, blindness and impotence

• Type 2 diabetes has been diagnosed in about two million people in the UK

• There is no cure, though it can be controlled by diet, exercise, weight loss and drugs

Saturday, 20 February 2010

Census discovers 5,000 marine species

Census discovers 5,000 marine species

By Victoria Gill
Science reporter, BBC News, San Diego

Hirsuta crab (COML)
The hirsuta crab was so unusual it warranted a whole new family designation

A preview of the Census of Marine Life has revealed that the project has discovered over 5,000 new species.

These include bizarre and colourful creatures, as well as many organisms that produce therapeutic chemicals.

A panel of scientists presented these early insights at the American Association for the Advancement of Science annual meeting in San Diego.

The final report from the decade-long census will be released in October 2010.

The project has involved more than 2,000 scientists from 80 countries, and the researchers involved believe the census will lay the scientific foundations for marine policies to protect vulnerable habitats.

Bottom trawling bulldozes through reef habitats that are thousands of years old
Jason Hall-Spencer
University of Plymouth

The researchers presented images of some of the most striking species discovered in the last decade, including a crab so unusual it warranted a whole new family designation. This member of the new Kiwaidae family of crabs, discovered near Easter Island, was named Kiwa hirsuta because of its furry appearance.

One member of the panel, Shirley Pomponi, a scientist from Florida Atlantic University, highlighted a new species of sponge.

This was found in the Florida Keys in August of 1999. Further investigation revealed that it produced a chemical with anti-cancer properties, which is now being investigated as a potential therapeutic.

Dr Pomponi said: "Adaptation to life in the sea has resulted in the production of chemicals that not even the most advanced computer program could produce.

"Mother nature still makes the best chemicals."

Bulldozing reefs

A major aim of the census is to provide the scientific support for the establishment of a global network of marine protected areas to prevent damage from fishing and other human activity.

Sponge (COML)
This new sponge produces a chemical with anti-cancer properties

Dr Jason Hall-Spencer, a marine biologist from the UK's University of Plymouth, said that delicate coral reefs were under threat from deep-sea trawling.

"All but one of the reefs I've looked at has been very badly damaged by bottom trawling - where a fishing net is dragged along the sea floor," he said.

"Bottom trawling bulldozes through reef habitats that are thousands of years old.

"But the good news is that we now have the data to change policy and work with fishermen to say where marine protected areas should be."

need for more NHS care at home

Burnham stresses need for more NHS care at home

Health Secretary Andy Burnham
Mr Burnham said more treatments must be offered outside hospitals

There must be a "decisive shift" in the NHS to provide more care in people's homes, the health secretary has said.

Andy Burnham said the health service must be more "confident" in being able to offer services, such as kidney dialysis, outside hospitals.

This could improve patient experiences as well as save billions, he added.

The Tories have pledged to put patients in the "driving seat", with people able to receive treatment for more minor ailments in their local communities.

'Patient convenience'

The Lib Dems say high-street pharmacists and the voluntary sector should play a role in supporting patients with long-term conditions and those with one-off medical queries or issues.

In a speech, Mr Burnham said: "The time has come for the NHS to make a decisive shift in providing more care out of hospitals and in the patient's community and home."

Integrating health services into the local community could save the NHS £2.7bn a year, he argued.

Last month, Gordon Brown unveiled plans to offer cancer sufferers free home care from specialist nurses, including access to chemotherapy.

What we know now is that we can safely do far more in the patient's home
Health Secretary Andy Burnham

And on Thursday, Mr Burnham told the BBC he wanted "to make the convenience of the patient the most important thing".

"It's about a personal NHS, a patient-centred NHS. For the individual, it's about bringing the services to them rather than vice versa," he said.

"Perhaps, in the past, the NHS has been a bit too much of a 'take it or leave it, like it or lump it' service.

"What we know now is that we can safely do far more in the patient's home, and at a local level, than we could before."

Taking the example of dialysis, he said it could have "a massive effect" on a patient's quality of life to be treated at home.

"It really can give them control back of their life, to balance work with treating their condition."

'Knock-about'

The health secretary restated Labour aims to provide more social care for the elderly at home and said he hoped a cross-party consensus could be reached.

He has called a conference on the issue on Friday, but the Conservatives have refused to attend unless Labour drops proposals for a "death tax".

A government Green Paper published last year suggested that one option for funding long-term care in England could be a compulsory levy of up to £20,000 which could be imposed after an individual's death.

"These issues are too important to be the stuff of normal knock-about," Mr Burnham said. "I think we do need to work across the political divide to find a sustainable solution for the long-term."

He also confirmed the government's intention to outline proposals on giving patients the right to die at home in future.

Friday, 19 February 2010

The African Union has condemned a coup in Niger

Col Goukoye Abdul Karimou read a statement signed by Col Salou Djibo

The African Union has condemned a coup in Niger, where soldiers have detained President Mamadou Tandja.

AU chief Jean Ping said he was watching developments "with concern" after a day of gun battles culminated in a takeover led by Colonel Salou Djibo.

West African bloc Ecowas "roundly condemned" the coup and dispatched a mission to talk to the plotters.

But one opposition activist told the BBC the soldiers were "honest patriots" who were fighting tyranny.

Heavy artillery

Mr Tandja provoked a political crisis last August when he changed the constitution of the uranium-rich country to allow him to remain in power indefinitely.

NIGER
Map of Niger
Chronic poverty
Population 14 million, 61% live on less than $1 a day
Resource rich
Huge reserves of uranium, Chinese firms digging for oil
Politcally unstable
History of coups, assassinations and on-off rebellion by nomadic Tuareg people in the north

Source: World Bank

Country profile: Niger

The Economic Community Of West African States (Ecowas), which suspended Niger after Mr Tandja's actions, said it had "zero tolerance" for any unconstitutional changes of government.

"We condemn the coup d'etat just as we condemn the constitutional coup d'etat by Tandja," Ecowas official Abdel Fatau Musa told the BBC's Network Africa programme.

He said the group had already sent a team to Niger and would maintain sanctions "until constitutional order is restored".

The BBC's Idy Baraou in the capital, Niamey, said on the morning after the coup, people in the city were going to mosques and shops as normal.

He said there was not an obvious military presence on the streets, but heavy artillery had been deployed around the presidential palace.

While state radio has been broadcasting military music overnight, state TV station Tele Sahel is continuing with live programming from a traditional wrestling championship.

Freedom fighters?

In a televised address on Thursday evening, a spokesman for the plotters announced that the constitution had been suspended and all state institutions dissolved.

The junta, which has called itself the Supreme Council for the Restoration of Democracy, imposed a curfew and closed the country's borders.

NIGER JUNTA
Col Salou Djibo
Coup leader
Col Djibrilla Hima Hamidou
Involved in 1999 coup
Col Goukoye Abdul Karimou
Junta spokesman
Col Amadou Harouna

The plotters said their aim was to restore democracy and save the population from "poverty, deception and corruption".

The move came after gunfights around the presidential palace reportedly resulted in several fatalities.

Soldiers captured Mr Tandja while he was chairing his weekly cabinet meeting, a government source told the BBC.

Little is known about coup leader Col Djibo, but another of the plotters, Col Djibrilla Hima Hamidou, was junta spokesman during the last military takeover in 1999.

The president was assassinated during that coup, but civilian rule was restored within a year.

One opposition activist, Mahamadou Karijo, whose Party for Democracy and Socialism has been bitterly opposed to Mr Tandja's rule, praised the soldiers for fighting tyranny.

"They behave like they say - they are not interested in political leadership, they will fight to save the Nigerien people from any kind of tyranny," he told Network Africa.

History of instability

The government and opposition had been holding on-off talks since December to try to resolve the country's political crisis.

President Tandja (file image)

Profile: Mamadou Tandja

Mr Tandja, a former army officer, was first voted into office in 1999 and was returned to power in an election in 2004.

His current whereabouts are unknown, but soldiers are thought to be holding him at a military base on the outskirts of Niamey.

Niger has experienced long periods of military rule since independence from France in 1960.

It is one of the world's poorest countries, but Mr Tandja's supporters argue that his decade in power has brought a measure of economic stability.

Under his tenure, the French energy firm Areva has begun work on the world's second-biggest uranium mine - ploughing an estimated $1.5bn into the project.

China National Petroleum Corporation signed a $5bn deal in 2008 to pump oil within three years.

Monday, 15 February 2010

HIV illness 'delayed by' herpes drug aciclovir

HIV illness 'delayed by' herpes drug aciclovir

Herpes virus
The HSV2 virus causes genital herpes

A common treatment for herpes can delay the need for HIV drugs in people with both infections, say US researchers.

A study of 3,300 patients in Africa found aciclovir reduced the risk of HIV progression by 16%, The Lancet reports.

Although a "modest" effect, the researchers said the cheap treatment was a simple way of keeping people with HIV healthy for longer.

One expert said it was important to note that aciclovir did not seem to make HIV patients less infectious.

The researchers from the University of Washington, Seattle, concentrated on people infected with HIV-1 - the most common type of infection.

While the HIV disease ameliorating effect we have observed is modest, it could add one more tool to help people with HIV infection stay healthy for longer
Dr Jairam Lingappa, study leader

It is known that most people who are infected with HIV-1 are also infected with herpes simplex virus type 2 (HSV2), or genital herpes.

Previous studies have shown that keeping the herpes virus suppressed reduces HIV levels but it was unclear whether this would slow down the disease.

Those in the trial were either given a twice daily dose of aciclovir or a dummy pill and then they were monitored for two years.

At the end of the study, 284 people on aciclovir had either started taking HIV medication, had a drop in CD4 count suggesting they should be on medication or had died. The comparable figure for patients taking the placebo was 324.

Use of aciclovir treatment did not reduce HIV transmission to their heterosexual partners.

More options

The researchers pointed out that HIV treatment with antiretroviral drugs would probably have a greater effect on reducing HIV disease progression than was seen with aciclovir.

But the herpes treatment may provide an additional option for individuals who have not reached medical thresholds for initiating antiretroviral therapy.

"Further investigation is needed to establish if suppression of this herpes virus has a role in HIV-1 treatment for people not eligible for antiretroviral therapy."

Study leader, Dr Jairam Lingappa, said: "While the HIV disease ameliorating effect we have observed is modest, it could add one more tool to help people with HIV infection stay healthy for longer."

Gus Cairns, editor of HIV Treatment Update, said: "It's nice to see a positive result in this field.

"There are biological reasons to believe that treating people's herpes could make them less likely to acquire HIV, or less likely to transmit it if they already have it, but results of trials testing the idea have been disappointing.

"Now at least we find that aciclovir, a very cheap, non-toxic and widely-available drug, can prolong the time some patients may be able to stay off the more expensive, and sometimes toxic, HIV drugs."

He added that the delay in HIV progression seen in the study may translate into a year or two off HIV medications.

"The only reservation I have is that aciclovir doesn't appear to make people less infectious, whereas the HIV drugs certainly do."

Saturday, 13 February 2010

New Tallest Man in the World!

London received a striking visitor today as the worlds newly-crowned tallest man, Turkish Sultan Kösen (26) who measures a staggering 8 ft 1 in (246.5 cm), toured the city in celebration of the lau...

The offensive began under cover of darkness

The offensive began under cover of darkness

Afghanistan conflict an 'information war'

By Jonathan Marcus
BBC News diplomatic correspondent

It's called shaping the battlefield. It's not the traditional air onslaught or artillery barrage designed to weaken an intended enemy before the offensive goes in.

British and Afghan soldiers share a laugh during preparations for Operation Moshtarak, in Shawrabad, Afghanistan, Feb 2010 (UK MoD)
Nato is keen to portray an image of co-operation and camaraderie

Instead it's now about shaping the information battlefield, because in Afghanistan - and in modern warfare in general - information has become the new front line.

At the very heart of Nato and the Pentagon, the disciples of the new art of "strategic communications" know that perceptions matter.

Nato's top commander in Afghanistan, Gen Stanley McChrystal, made this point explicitly in a recent interview.

"This is all a war of perceptions. This is not a physical war in terms of how many people you kill or how much ground you capture, how many bridges you blow up. This is all in the minds of the participants."

Any information you send out carries with it a variety of messages.

'Telegraphed'

Take the current operation in Helmand. It has been broadcast widely in advance. It even has a not-so-catchy title: Operation Moshtarak, which in Dari translates as "together".

Gen Stanley McChrystal in Kabul, Jan 2010
Gen McChrystal has called the Afghan conflict a "war of perceptions"

So there you have it, already three messages, if not more.

The operation's title is in a local language and it stresses the idea of partnership - doubly signifying that this is a joint operation between Nato and Afghan government forces doing the job "together".

The advance warning too sends a crucial signal - it is part of a deliberate and explicit strategy to encourage civilians to take precautions; to calm and inform tribal leaders; and perhaps to encourage some Taliban fighters to make themselves scarce.

"This operation has certainly been telegraphed in advance far more than previous operations," one Nato insider said, "but the alliance has been doing this kind of thing for some time.

"The message is clear. We are determined to take the area, but in such a way as to minimise violence", the official said. "But if we have to fight for it, we will win."

'Psy-ops'

That sounds just a bit more like the traditional kind of message you would expect at such a time, but the reality is that on the information battlefield, just as in operations on the ground, things have changed dramatically.

The danger is that if things on the ground get messy, there will be no hiding from it
Michael Clarke
Royal United Services Institute

What began as inducement or encouragement for troops to lay down their arms, or basic instructions to civilians not to get in the way of military operations - think leaflets dropped by aircraft in World War II - has blossomed into almost a social science of cause and effect.

Psychological operations or "psy-ops" of the 1950s have morphed into information warfare.

There have been uneasy debates about where the boundary line between this and the traditional press officer's role should be, because, let's face it, the media is an involuntary actor in this drama too.

However the new discipline of strategic communications seeks to go beyond information operations, press briefings and leaflet drops. It is, in the words of one alliance official, "an over-arching concept that seeks to put information at the very centre of policy planning."

When you are fighting wars within communities in an effort to secure popular support for one side or another - the traditional struggle for hearts and minds - you can see how central the concerns of the new strategic information warriors have become.

In some ways, this is at the very core of modern counter-insurgency strategy.

'No hiding'

However there are limitations, not least those related to the ubiquity of the modern mass media.

In strategic communications, the messages you are sending must fit the facts on the ground
Nato 'information warrior'

As Michael Clarke, director of the Royal United Services Institute in London, said: "Strategic communications can only ever give out one message. They've tried in the past to put out split messages and it doesn't work."

So much of what people hear in Helmand province, they also hear in Britain and in other troop-contributing countries.

"There's a positive side to this," says Mr Clarke, "It's a consistent message, but the danger is that if things on the ground get messy, there will be no hiding from it." The information frontline is in effect everywhere.

This growing centrality of information and the need to shape perceptions inevitably prompts critics to suggest that this is all not so new after all - isn't it just one huge propaganda exercise writ large?

Not surprisingly, one of the new Nato information warriors disagrees.

"In strategic communications, the messages you are sending must fit the facts on the ground," he says. "The discipline is about bringing perceptions and reality together to achieve an effect."

'Untidy end'

Many critics may remain unconvinced seeing the whole thing as a giant spin-machine intended to accentuate the positive and present one particular carefully-controlled narrative of events.

Taliban fighters in Ghazni province, January 2010
Advance warning has been sent to Taliban leaders and militants

Because that, in a sense, is what is at stake - it is a battle for the narrative.

Whose interpretation of what is happening is going to prevail? This new focus raises uncomfortable questions for anyone involved in the information business. Perceptions matter in another way too.

There is unlikely to be a tidy end to the Afghan conflict. Nobody really can define what "victory" or "defeat" in the traditional sense might mean.

So if it is to be an untidy conclusion then what people think about it - how they judge the outcome - really does matter.

It used to be said that: "Britain won its wars on the playing fields of Eton."

But now a new kind of warfare means that the information battle has to be fought on multiple fronts by multiple actors.

From the fields of Helmand to the small towns of Kansas; from the tribal areas of Pakistan to British cities where voters are girding themselves for a coming election, the news from the Afghan battle-front will shape perceptions - and these perceptions will inevitably shape future policy

-led forces say they are making good progress hours after launching the biggest offensive in Afghanistan since the overthrow of the Taliban in 2001.

There were clashes as more than 15,000 US, UK and Afghan troops swept into the Helmand districts of Marjah and Nad Ali in a bid to secure government control.

The Afghan regional commander said 20 militants had been killed. Two Nato soldiers are confirmed to have died.

A Taliban commander reportedly said his men were retreating to spare civilians.

Operation Moshtarak - which means "together" in the local Dari language - is being led by 4,000 US Marines, supported by 4,000 British troops, with Canadians, Danes and Estonians.

'Heavily booby-trapped'

The BBC's Frank Gardner, with Nato forces at Kandahar airbase, says the test of the operation's success will not be on the battlefield.

AT THE SCENE
Ian Pannell
Ian Pannell
BBC News, Nad Ali
It's been a very successful day for British forces. They were able to move into several key villages and establish a foothold.

Broadly speaking, they met little resistance. There was sporadic gunfire. One RPG was fired over the location where we are based.

It's fair to say that the Taliban decided to move out of the district. Many civilians have also left, and the challenge in the coming days and weeks is to persuade them to come back, to establish meaningful security and then allow meaningful governance to take place.

What will make a difference is if there is meaningful security established and if the local people feel confident enough to place their faith in local security forces.

This is an operation that has only just begun and it will take weeks and months before we know how successful it has been.

Operation Moshtarak: Diary

It all depends on whether the coalition can hold the ground and bring lasting security and good governance to the population of central Helmand.

A spokesman for Nato's Isaf force has confirmed to the BBC that two soldiers have been killed in Operation Moshtarak.

One died in an improvised explosive device (IED) attack and another from small-arms fire. No further information has been released on the location.

Three US soldiers were also killed by an IED, Nato said, although it is not clear whether they were part of Operation Moshtarak.

Mohammad Zazai, commander of Afghan troops in the operation, said: "So far, we have killed 20 armed opposition fighters. Eleven others have been detained." The casualties and captures were in separate incidents.

Troops have been advancing carefully, picking their way through poppy fields, trying not to set off Taliban bombs.

A canal bridge into Marjah was so rigged with explosives that US Marines had to erect temporary crossings to reach the town, reports the Associated Press.

Helmand Governor Gulab Mangal told a news conference the Taliban had "heavily booby-trapped the area".

Marjah resident Abdul Wahaab told AFP by telephone as he and his family left the town: "We were sleeping when all of a sudden we heard this horrible noise - it was helicopters bringing in soldiers.

"As we were crossing the village we saw US and Afghan soldiers on the junctions. There were lots of them."

Afghan President Hamid Karzai, who approved Operation Moshtarak, warned troops to avoid civilian casualties, and called on Taliban fighters to lay down their weapons.

Nato says Marjah is home to the biggest community under insurgent control in the south.

'On the hop'

It was estimated there were between 400 and 1,000 militants based there before Operation Moshtarak was launched.

MARJAH: 'TALIBAN STRONGHOLD'
Town and district about 40km (25 miles) south-west of Lashkar Gah
Lies in Helmand's 'Green Zone' - an irrigated area of lush vegetation and farmland
Last remaining major Taliban stronghold in southern Helmand
Area considered a centre for assembling roadside bombs
Key supply centre for opium poppies - lucrative revenue source for Taliban
Estimates of Taliban numbers range up to 1,000
Population of Marjah town put at 80,000 while the whole of Marjah district is thought to have 125,000

Who are the Taliban?
Conflict reaches critical juncture
Details on Operation Moshtarak

Marjah has also long been regarded as a linchpin of the lucrative network for smuggling opium - the raw ingredient used to make heroin - harvested from Helmand's poppy fields.

Nato Commander Maj Gen Nick Carter told the BBC the offensive had been "so far extremely successful".

"Indeed it would appear that we've caught the insurgents on the hop - he appears to be completely dislocated," he said.

Later at a Ministry of Defence briefing in London, Maj Gen Gordon Messenger said the UK force of more than 1,000 troops had secured their "key objectives" at the start of Operation Moshtarak.

The offensive began with waves of helicopters ferrying US Marines into Marjah in the early hours of Saturday.

British troops then flew into Nad Ali district, to the north, followed by tanks and combat units.

HAVE YOUR SAY
We have little choice. We pull out, Pakistan falls. This is the era of the new domino theory.
David Cheshire, Dorset, UK
Send us your comments

Jets and helicopters fired missiles at Taliban positions.

The BBC's Ian Pannell in Nad Ali says the vast majority of villagers seem to have left the area to avoid getting caught in crossfire between the Taliban and Nato troops.

Mullah Mohammed - a Taliban commander in Marjah - told ABC News that his men were pulling back to spare any civilian casualties.

"We found civilians in massive danger so we decided to go backward just to save villagers' lives," he said. His claim cannot be verified.

Nato had distributed leaflets in the Marjah area warning of the planned offensive in a bid to limit civilian casualties.

It is the first major offensive since US President Barack Obama ordered a "surge" of 30,000 extra troops to Afghanistan in December.

More than 1,900 Afghan police will provide support after the initial military operations end, and a large team of Afghan administrators has been assembled.

The operation is part of an effort to secure a 320-km (200-mile) horseshoe-shaped string of towns that runs along the Helmand River, through Kandahar and on to the Pakistani border.

The area holds 85% of the population of Kandahar and Helmand.

Climate data 'not well organised'

Climate data 'not well organised'

By Roger Harrabin
Environment analyst, BBC News

Professor Phil Jones
Professor Jones says he regrets not sharing raw data

Phil Jones, the professor behind the "Climategate" affair, has admitted some of his decades-old weather data was not well enough organised.

He said this contributed to his refusal to share raw data with critics - a decision he says he regretted.

But Professor Jones said he had not cheated over the data, or unfairly influenced the scientific process.

He said he stood by the view that recent climate warming was most likely predominantly man-made.

But he agreed that two periods in recent times had experienced similar warming. And he agreed that the debate had not been settled over whether the Medieval Warm Period was warmer than the current period.

These statements are likely to be welcomed by people sceptical of man-made climate change who have felt insulted to be labelled by government ministers as flat-earthers and deniers.

'Bunker mentality'

Professor Jones agreed that scientists on both sides of the debate could suffer sometimes from a "bunker mentality".

He said "sceptics" who doubted his climate record should compile their own dataset from material publicly available in the US.

"The major datasets mostly agree," he said. "If some of our critics spent less time criticising us and prepared a dataset of their own, that would be much more constructive."

His colleagues said that keeping a paper trail was not one of Professor Jones' strong points. Professor Jones told BBC News: "There is some truth in that.

"We do have a trail of where the (weather) stations have come from but it's probably not as good as it should be," he admitted.

"That's similar with the American datasets. There were technical reasons for this, with changing data from different countries. There's a continual updating of the dataset. Keeping track of everything is difficult. Some countries will do lots of checking on their data then issue improved data so it can be very difficult. We have improved but we have to improve more."

His account is the most revealing so far about his decision to block repeated requests from people demanding to see raw data behind records showing an unprecedented warming in the late 20th Century.

Professor Jones said climate scientists needed to do more to communicate the reasons behind their conclusion that humans were driving recent climate change.

They also needed to be more transparent with data - although he said this process had already begun.

He strongly defended references in his emails to using a "trick" to "hide the decline" in temperatures.

These phrases had been deliberately taken out of context and "spun" by sceptics keen to derail the Copenhagen climate conference, he said.

And he denied any attempt to influence climate data: "I have no agenda," he said.

"I'm a scientist trying to measure temperature. If I registered that the climate has been cooling I'd say so. But it hasn't until recently - and then barely at all. The trend is a warming trend."

He said many people had been made sceptical about climate change by the snow in the northern hemisphere - but they didn't realise that the satellite record from the University of Alabama in Huntsville showed that January had been the warmest month since records began in 1979.

Archbishop Vincent Nichols attacks NHS over compassion

Archbishop Vincent Nichols attacks NHS over compassion

Archbishop Vincent Nichols
Archbishop Vincent Nichols will reject calls for assisted suicide

The leader of the Roman Catholic Church in England and Wales is to use a homily to criticise what he sees as a lack of compassion in some parts of the NHS.

Archbishop Vincent Nichols will say that some hospitals see patients as no more than a set of medical problems.

He will say calls for assisted suicide and euthanasia reflect a society that does not know how to deal with death.

The archbishop's comments will be delivered at a special service of healing at Westminster Cathedral.

Prevailing culture

He will say the constitution of the NHS promises to respond with humanity to a patient's distress and anxiety as well as their pain.

But the archbishop will claim some hospitals fail to meet that commitment because of a prevailing culture which sees patients as no more than medical cases to be resolved.

He will say systems of care have been created which by treating patients in this way inflicts what amounts to hidden violence on them.

The archbishop will also say society is at a loss to know how to respond to death.

He will reject calls for assisted suicide, accusing its supporters of wrongly seeing death as simply a medical event.

Friday, 12 February 2010

Brain clue may explain autism 'hug avoidance'

Brain clue may explain autism 'hug avoidance'


Mutated chromosome in ragile X
A bent X chromosome like the one above is characteristic of the condition
Delays at crucial points during the development of the brain in the womb may explain why people with a condition linked to autism do not like hugs.
A study in mice with fragile X syndrome found wiring in the part of the brain that responds to touch is formed late.
The findings may help explain why people with the condition are hypersensitive to physical contact, the researchers wrote in Neuron.
It also points to key stages when treatment could be most effective.
Fragile X syndrome is caused by a mutant gene in the X chromosome that interferes in the production of a protein called fragile X mental retardation protein (FMRP).
Under normal circumstances, the protein directs the formation of other proteins that build synapses in the brain.
It also has implications for the treatment of autism since the changes in the brains of fragile X and autistic people are thought to significantly overlap
Professor Peter Kind,
Study author
Boys are usually more severely affected with the condition - which is the leading known cause of autism - because as they have only one X chromosome.
In addition to mental impairment, hyperactivity, emotional and behavioural problems, anxiety and mood swings, people with fragile X also show what doctors call "tactile defensiveness", which means they do not make eye contact and do not like physical contact and are hypersensitive to touch and sound.
Connections
By recording electrical signals in the brains of mice, bred to mimic the condition, the researchers found that connections in the sensory cortex in the brain were late to mature.
This "mistiming" may trigger a domino effect and cause further problems with the correct wiring of the brain, they concluded.
The study also found these changes in the brain's connections occur much earlier than previously thought, midway through a baby's development in the womb.
And it suggests there are key "windows" when treatments for fragile X and autism could be most effective, they said.
Professor Peter Kind, who led the study at the University of Edinburgh, added: "We've learned these changes happen much earlier than previously thought, which gives valuable insight into when we should begin therapeutic intervention for people with these conditions.
"It also has implications for the treatment of autism since the changes in the brains of fragile X and autistic people are thought to significantly overlap."
Dr Gina Gómez de la Cuesta, from the National Autistic Society, said research into fragile X syndrome could help understanding of certain aspects of autism.
"Autism is common in people with fragile X syndrome, however there are many other causes of autism, most of which are not yet fully understood.
"Understanding how the brain works when a person has fragile X syndrome could help put some of the pieces together about what is happening in the brain when a person has autism, but it is not the whole story.
"Animal research can tell us a lot about genetics and the brain, but it is only a small part of the picture and further research would be required before we fully understand any links to autism."

Thursday, 11 February 2010

Rajendra Pachauri, chairman of the UN's Intergovernmental Panel on Climate Change since 2002, has been under fire on two fronts: a glaring error in th

Profile: Climate chief Rajendra Pachauri



Rajendra Pachauri, chairman of the UN's Intergovernmental Panel on Climate Change since 2002, has been under fire on two fronts: a glaring error in the body's reporting on glaciers and his business dealings.
Rajendra Pachauri at a news conference in Delhi, 21 January He has rejected calls to resign, arguing that he is being targeted by countries and companies reluctant to embrace greener technology for economic reasons, and insisting that money he earns as a consultant goes straight back into a research institute which he heads.
The IPCC chairman is Indian and his office's website portrays the 69-year-old engineer and economist as an "incredible" success story for his country.
"The name of Dr Rajendra K Pachauri... has become synonymous with climate change and the environment," its biography says.
"Dr Pachauri is now on everyone's wish list for their climate change events."
'Work ethic'
Born on 20 August 1940 in the Nainital district of the outer Himalayas, Dr Pachauri is the son of a London University-educated educational psychologist, according to the biography.
He attributes to his mother his "well-known work ethic, entailing strict punctuality and completion of all tasks".
Privately educated in Lucknow, he went on to study mechanical engineering and, after managerial work at an Indian railway company, pursued an academic career which led to US teaching posts, in North Carolina and Virginia.
The year 1982 saw him in the Indian capital, Delhi, where he took over as director of The Energy Research Institute (Teri), a think tank promoting sustainable development.
In the 1990s, Dr Pachauri began working in various capacities for the UN and helped with the research that resulted in the Kyoto Protocol of 1997.
In 2002, he was serving as a vice-chairman of the IPCC when he was elected to the chairman's post itself, ousting Robert Watson.
Dr Pachauri, who was returned to the post in 2008, was the favoured candidate of the US Bush administration which reportedly disliked Dr Watson's willingness to tell governments what he believed to be the unvarnished truth - that human activities were contributing dangerously to climate change.
The Indian chairman has been honoured for his work on climate change with state awards in India and France.
His biography says he relaxes by composing poetry and playing cricket.
A prolific writer of academic reports, he raised eyebrows in January 2010 with the publication of a steamy novel about an Indian climate expert's life and times in India, Peru and the US.
A review of Return to Almora in the Daily Telegraph newspaper notes the novel's initial theme of deforestation, then quips that "talk of 'denuding' is a clue of what is to come", and details the book's sex scenes.
'Not a penny'
In January 2010, the IPCC admitted it had made a mistake in asserting that Himalayan glaciers could disappear by 2035, a date it included in its 2007 assessment of climate impacts.
With the IPCC struggling to forge a binding international agreement on reducing greenhouse gases, the error boosted sceptics who accuse climate campaigners of alarmism, and led to calls for Dr Pachauri to resign.
Speaking to the BBC, the IPCC chairman said the mistake had been publicly corrected and insisted that there was a huge volume of evidence validating the science of global warming.
He denied that controversy surrounding his position was distracting from the work of the IPCC.
"I don't think the world is going to be distracted," he said. "I don't think the scientific community is going to be distracted."
Dr Pachauri also dismissed UK press allegations that he has made a fortune from carbon trading thanks to links between Teri and private companies.
Any money he earned from advising companies went to Teri, he said, adding: "Not a single penny goes into my pocket."

Swine flu drugs ordering service is closed down

Swine flu drugs ordering service is closed down

Swine flu vaccines
Millions of swine flu vaccines were bought in preparation

The National Pandemic Flu Service, set up to dispense drugs to patients in England without the need to see doctors, has closed down.

The closure - at 0100 GMT - came after a sharp decline in the number of cases of the H1N1 swine flu virus.

Health officials said the hotline and website could be restored in seven days should the situation change.

But parents with young children are still being advised to have them immunised against the disease.

At its peak, 40,000 people a week received antivirals through the National Pandemic Flu Service.

But the figure has now fallen to below 5,000 a week.

About five million of the 90 million doses of antiviral drugs that were made available were actually dispensed.

The virus may not be around at the moment but it could come back
Sir Liam Donaldson
Chief Medical Officer for England

England was the only part of the UK to use the system, which allowed people to get Tamiflu by answering a series of tick-box questions.

Anyone who thinks they have flu can still check their symptoms online.

If they still have concerns they can contact NHS Direct (NHS24 in Scotland) or call their GP.

Chief Medical Officer for England Sir Liam Donaldson has repeated his call for parents of children aged six months to under five to have them immunised - even though cases of swine flu are very low.

He said: "The virus may not be around at the moment but it could come back".

However, Sir Liam denied the government had over-reacted.

Dr Sarah Jarvis, a GP from London, agreed vulnerable groups were still at risk.

She said: "Elderly people who have other medical conditions, young people, children under five, and pregnant women do seem to have been really disproportionately represented in the people who've had really nasty complications.

"So the question is - the risk is probably quite small now, but would you ever forgive yourself if your child didn't have the vaccination and ended up getting the infection and getting a really nasty complication?"

An announcement is expected in around 10 days regarding what the government will do with its remaining stocks of vaccine.

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