Showing posts with label autism. Show all posts
Showing posts with label autism. Show all posts

Friday, 19 December 2014

Autism link to air pollution raised

Autism link to air pollution raised

Woman with face mask

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A link between autism and air pollution exposure during pregnancy has been suggested by scientists.
The Harvard School of Public Health team said high levels of pollution had been linked to a doubling of autism in their study of 1,767 children.
They said tiny particulate matter, which can pass from the lungs to the bloodstream, may be to blame.
Experts said pregnant women should minimise their exposure, although the link had still to be proven.
Air pollution is definitely damaging. The World Health Organization estimates it causes 3.7 million deaths each year.
The study, published in Environmental Health Perspectives, investigated any possible link with autism.
Pollutants
It analysed 245 children with autism and 1,522 without.
By looking at estimated pollution exposure during pregnancy, based on the mother's home address, the scientists concluded high levels of pollution were more common in children with autism.
The strongest link was with fine particulate matter - invisible specks of mineral dust, carbon and other chemicals - that enter the bloodstream and cause damage throughout the body.
ExhaustNitrogen dioxide is a by-product of diesel engines
Yet, the research is unable to conclusively say that pollution causes autism as there could be other factors that were not accounted for in the study.
Consistent pattern
There is a large inherited component to autism, but lead researcher Dr Marc Weisskopf said there was mounting evidence that air pollution may play a role too.
He said: "The specificity of our findings for the pregnancy period, and third trimester in particular, rules out many other possible explanations for these findings.
"The evidence base for a role for maternal exposure to air pollution increasing the risk of autism spectrum disorders is becoming quite strong.
"This not only gives us important insight as we continue to pursue the origins of autism spectrum disorders, but as a modifiable exposure, opens the door to thinking about possible preventative measures."
Prof Frank Kelly, the director of the environmental research group at King's College London, told the BBC: "I think if it was this study by itself I wouldn't take much notice, but it's now the fifth that has come to the same conclusion.
"It is biologically plausible, the placenta is there to ensure the foetus has optimal supply of nutrients, but if chemicals are entering the mother's body then the foetus will have access to those too.
"Women should be made aware of the potential links so they don't get excessive exposure."

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Monday, 3 November 2014

genetic risks for autism ?

Study points to new genetic risks for autism

DNA sequenceThe study linked 33 genes to autism.

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A massive international study has started to unpick the "fine details" of why some people develop autism, researchers have said.
They looked at thousands of DNA samples from children with autism and their parents.
The results, in the journal Nature, linked 33 genes to the condition with many involved in brain development.
The National Autistic Society said we were still "a long way" from knowing the cause of autism.
The study suggested a number of different risk factors for the condition, according to the lead author of the paper Prof Joseph Buxbaum, from Icahn School of Medicine at Mount Sinai New York.
"The smoking gun is genetics - but there are quite a lot of different bullets in the gun," said Prof Buxbaum.
DNA analysis
Autism is a life-long disorder that affects people's ability to socialise, and those on the autism spectrum can find it difficult to interact with other people.
The researchers assessed 15,480 DNA samples to determine the impact of mutations to the DNA that are passed from parent to child as well as those that spring up spontaneously.
The study expanded the number of genes linked to autism up to 33.
Seven genes were completely new while 11 had not been classed as true risk genes due to lack of data. Fifteen of the genes were already known to be risky.
It also indicated that small, rare genetic mutations in 107 genes can contribute to the risk of autism.
More than 5% of the autistic people in the study had these non-inherited loss-of-function gene mutations.
'Finer detail'
The study should help to improve understanding of some of the causes of autism, said Prof David Skuse, head of the social communication disorders team at Great Ormond Street Hospital in London, and a contributor to the report.
"Up until now we've really not been able to understand the mechanisms that lead to autism," he said. "This [study] is getting down to much finer detail."
Prof Skuse added that the study could start to help families understand autism.
The National Autistic Society (NAS) said there were many gaps in autism knowledge.
Carol Povey, director of the NAS Centre for Autism, said: "Autism is a highly complex story of genes not only interacting with other genes, but with non-genetic factors too.
"Research like this helps us to understand the genetics involved in certain forms of autism and opens up the possibility of whole families gaining a better understanding of a condition they may share," she said.
"However, we are still a long way from knowing what causes autism. What people with the condition, their families and carers need most of all, is access now to the right kind of support to be able to lead full lives," she added.

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Tuesday, 10 December 2013

Susan Boyle reveals Asperger's Syndrome diagnosis

Susan Boyle reveals Asperger's Syndrome diagnosis

Susan BoyleSusan Boyle said she could now "better understand" herself after the diagnosis

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Scottish singer Susan Boyle has revealed she has been diagnosed with Asperger's Syndrome.
The star, who shot to fame after appearing on Britain's Got Talent in 2009, had spent years believing she suffered slight brain damage at birth.
In an interview with The Observer newspaper she told of her relief at finally getting a "clearer understanding" of her condition.
But she vowed: "It will not make any difference to my life."
Asperger's is a form of autism which typically means people with the condition struggle with their emotions and have difficulty in social situations, often unable to pick up on non-verbal cues.
'Greater understanding'
Boyle, 52, revealed she was misdiagnosed after complications at birth.
She said: "It was the wrong diagnosis when I was a kid.
"I was told I had brain damage. I always knew it was an unfair label. Now I have a clearer understanding of what's wrong and I feel relieved and a bit more relaxed about myself."
The singer has gone on to become one of the best-selling British female artists and recently had a cameo role in the festive film The Christmas Candle.
Last year a musical based on her life toured cities in the UK and Republic of Ireland and she has also said a film about her rise to fame is being planned.
Boyle said of her recently diagnosed condition: "It will not make any difference to my life. It's just a condition that I have to live with and work through.
"I think people will treat me better because they will have a much greater understanding of who I am and why I do the things I do."

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Tuesday, 3 December 2013

male and female brains different


Boy in autism studyMost autism research involves boys and men

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Autism affects male and female brains differently, a study has suggested.
UK experts studied brain scans of 120 men and women, with half of those studied having autism.
The differences found in the research, published in journal Brain, show more work is needed to understand how autism affects girls, the scientists say.
Experts said girls with the condition could be more stigmatised than boys - and it could be harder for them to be diagnosed at all.
Autism affects 1% of the population and is more prevalent in boys, so most research has focused on them.
In this study, scientists from the Autism Research Centre at the University of Cambridge used magnetic resonance imaging (MRI) to examine how autism affects the brain of males and females.
Male and female brains differ anyway - tissue volume is greater in males.
'Look-alikes'
The study looked at the difference between the brains of typical males and those with autism - and then females with and without autism.

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There really needs to be more research and clinical attention toward females 'on the spectrum'”
Dr Meng-Chuan LaiUniversity of Cambridge
They found the brains of females with autism "look" more like - but still not the same as - typical male brains, when compared with the brains of females without autism.
But the same kind of difference was not seen in males with autism - so their brains did not show "extreme" male characteristics.
Dr Meng-Chuan Lai, who worked on the study said: "What we have known about autism to date is mainly male-biased.
"This research shows that it is possible that the effect of autism manifests differently according to one's gender.
"Therefore we should not blindly assume that everything found for males or from male-predominant mixed samples will apply to females."
He said future research may need to look at males and females equally to discover both similarities and differences.
Dr Lai added: "Lastly, there really needs to be more research and clinical attention toward females 'on the spectrum'."
'Masking'

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Many girls go on to develop secondary problems such as anxiety, eating disorders or depression”
Carol Povey,National Austitic Society
Carol Povey, Director of The National Autistic Society's Centre for Autism, said: "Historically, research on autism has been largely informed by the experiences of men and boys with the condition.
"This important study will therefore help our understanding of how the condition differs between genders."
She added: "Girls can be more adaptive than boys and can develop strategies that often mask what we traditionally think of as the signs of autism.
"This "masking" can lead to a great deal of stress, and many girls go on to develop secondary problems such as anxiety, eating disorders or depression.
"It's important that we build on this study and more research is conducted into the way autism manifests in girls and women, so that we can ensure that gender does not remain a barrier to diagnosis and getting the right support."

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Friday, 3 May 2013

MMR jab: Somali migrants have lingering fears on autism


MMR jab: Somali migrants have lingering fears on autism

A measles vaccination kit

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Health officials say vaccination rates against measles are worryingly low among Somali children in the US and UK because some parents still believe the MMR jab is linked to autism.
The officials say they are struggling to show that the vaccination is safe.
BBC Radio 4's The Report has found that the discredited former doctor Andrew Wakefield visited some Somali groups in the US.
Health authorities there blame him for the drop-off in MMR vaccinations.
Andrew Wakefield, who now lives in Texas, says Somalis in Minnesota already had fears about autism and MMR before his visit.
Somali Bakita Mohamed Haji lives in north-west London with her 10-year-old daughter, who suffers from autism.
Fears reinforced
She says her daughter's condition started after she was given the jab.
"My daughter was born normally but when I started the MMR, my daughter changed. Screaming all the time, crying. I went to the hospital and they said it's autism. I don't understand it. I'd never heard of it."

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A number of individuals reached out to the community who planted the seed that there might be concerns about vaccination”
Kristen EhresmannMinnesota department of health
She wishes her daughter had never had the injection, which she believes caused the condition.
Health experts say her fears, and those of other parents, have been reinforced by a common belief in their community that only the children of Somali families that emigrate to the West develop autism, whereas those who stay at home do not.
While there is no solid evidence to confirm this, a small study of immigrants in Stockholm, the Swedish capital, did suggest that families using services for autistic children were more likely than expected to be from West and East Africa.
Discredited study
And separate research in the UK also found there was a higher than average incidence of autism in children born to African mothers - but it did not establish a reason why.
The fears of Somali parents echo those sparked by a study in The Lancet medical journal that linked MMR with autism.
The study was discredited and withdrawn. Andrew Wakefield, the lead author, was struck off by the General Medical Council because of ethical concerns about his methods.

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Coloured Transmission Electron Micrograph of a section through a human cell infected with the measles virus
For more details of how to listen again, go to The Report website.
A subsequent raft of research has found no link between the MMR vaccine and autism, and average vaccination rates are back up to 94% in England for five-year-olds receiving the first dose of MMR.
Parents frustrated
But take-up of the vaccine is much lower among Somali children in the UK and in the US.
In Minnesota in the Midwest, the Somali American Autism Foundation has pledged to find out what causes the condition in their children.
Idil Abdul runs the foundation and has a son, 10, who is autistic.
"If your child is sick, the goal is you take them to the doctor and the doctor tells you what's wrong with the kid and how to make him better. With autism, we go to the doctor and they say, 'We don't have a cause, we don't have a cure, too bad, so sad, you might not get access to early intervention, have a nice day.'"

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It is very difficult to dislodge beliefs from whatever community if they're dealing with a disease that isn't adequately explained”
Prof David SalisburyDirector of immunisation at the Department of Health
She does not believe there is a link between MMR and autism but says parents are frustrated because they do not feel their concerns are being listened to by the authorities.
'Planted the seed'
Andrew Wakefield visited Minnesota at least three times between 2010 and 2011, promising research to find answers to their questions.
The Minnesota department of health says his visit contributed to a drop-off in MMR uptake among Somalis and says only around 50% of Somali children now receive the vaccine.
Kristen Ehresmann, the state's director of infectious disease, believes he had an influence on Somali perspectives.
"There were a number of individuals who reached out to the community who planted the seed that there might be concerns about vaccination and what role it could play.
"Since that time we've seen vaccination rates drop off accordingly."
Andrew Wakefield denies his visit caused the drop in Somali children having the MMR jab, claiming the trend was already happening.
'Vaccination champions'
He said: "The reason that I was invited was to help address the Somalis' pre-existing fears about developmental regression in their children following MMR immunisation."
Although there are no official statistics, vaccination rates are also believed to be low among Somali children in London.
Shukri Osman, a parent of an autistic child, estimates that only half the Somali parents she knows have taken up the vaccine.
And in Brent, the area in north-west London where she lives, the council says low uptake in the Somali community has been recognised for a number of years.
It is currently training up "community vaccination champions" and now has an immunisation team with Somali-speakers.
Engrained perceptions
Prof David Salisbury, the director of immunisation at the Department of Health, said: "We know that there is not an association between MMR and autism, and that I'm sure has been said many times to Somali community leaders."
But even he admits it will be hard to change what may have become engrained perceptions.
"I think we know it is very difficult to dislodge beliefs from whatever community if they're dealing with a disease that isn't adequately explained on the basis of the cause. "
You can listen again to The Report on BBC Radio 4 via the Radio 4 website or The Report download.

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Wednesday, 19 December 2012

Ambitious about Autism guide


Tips for an autism-friendly Christmas


Emma Tracey Emma Tracey | 15:01 UK time, Friday, 14 December 2012
Dylan and Jake Beadle in the snow with mum Tracy
Most of us see Christmas as a welcome excuse to break from the old routine, do lots of socialising and give and receive presents. But the holidays can prove challenging for children and adults on the autistic spectrum, who find change, crowds and surprises difficult to handle.
That's why Ambitious about Autism and the National Autistic Society have both thought to produce their own online guides to help people with ASD, and their families, to cope with Christmas time.
Tracy Beadle, mother of two children who are on the autistic spectrum, is one of the contributors to the Ambitious about Autism guide which has been crowd-sourced via social media and their Talk about Autism forums.
Her sons, seven-year-old Dylan Beadle and his four-year-old brother Jake both love Christmas but their social difficulties, sensitivities about touch, taste and noise, and untypical reactions to certain situations, have led mum Tracy and dad Glen to approach this part of the year a little differently.
Christmas preparations start for the family in late November to get Dylan and Jake ready for changes at home.
"We give the boys a count down of 'sleeps' before the decorations go up, and then again before they come down," Tracy says.
"A visual calendar is then hung in their bedroom and every night we stand and count the sleeps until Christmas Day."
The calendar is a sheet of paper with a square representing each day. All other squares are blank apart from Christmas Day which has present-bedecked stickers on it.
Both of the online guides appreciate that all children are different, so what works for one may not suit another.
The National Autistic Society suggests that some might benefit from having more events marked on their visual calendar, such as when the school holidays begin and end, when they can expect visitors and so on.
Finding out when preparation will begin at your child's school and then starting your family Christmas at home at the same time is another suggestion.
One Christmas inevitability for children is the annual school performance. Tracy's eldest son Dylan isn't a fan. "He has cried his way through the last three, so he isn't going to take part this year. It upsets him and it isn't an essential life skill."
Younger son Jake hopes to be in his school nativity play but Tracy says this took some work: "He went mad when he saw his shepherd's outfit, and said 'I go to school as a boy, not a shepherd'."
They took the costume in to school and introduced Jake to it slowly. He had learned the songs and was eager to go on stage, so after some encouragement from the teacher, Jake has been convinced to wear the robes during the show.
A fear of people in costume means that visiting Santa is not part of the Beadles' Christmas routine.
"We took Dylan once," Tracy remembers. "He was the only child there who, instead of sitting on Santa's lap, sat on a toy car and started playing with it. He wouldn't speak to Santa at all."
Like many others with autism, Jake and Dylan aren't good at faking delight if they get an unwanted gift. Friends and relatives now always ask mum and dad what the boys would like. For Tracy, this is an easy one to answer.
"They do tend to have an obsession each Christmas," she says. "It is Angry Birds this year. Last year it was Disney's Cars."
Tracy is aware of parents who discourage their autistic child's obsessions but she takes a different approach. "I completely over-indulge the obsessions, buying them every toy they want because I find that if you over-indulge them, it passes more quickly."
Both guides have plenty of tips for managing Christmas Day. Advice includes putting batteries in toys in advance so that they can be played with straight away and making sure that the Christmas meal is ready at a prearranged time.
The consensus, though, is to find a routine that works and stick to it. Through trial and error, Tracy and Glen Beadle have found a pattern of events which the boys like and which they expect to happen. So, what's their pattern?
"On Christmas Eve we go to visit my nan," says Tracy. "On the way home we take them to visit a house with thousands of pounds worth of decorations. On Christmas Day, we open presents and then my immediate family come for dinner."
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Saturday, 21 April 2012

Louis Theroux on autism


Louis Theroux on autism: A very different sort of school

Louis Theroux with students from the DLC Warren
With autism diagnoses rising more and more parents are plunged into a battle to understand the condition and find their child the right treatment, writes Louis Theroux.
Joey Morales-Ward is a 13-year-old kid who lives in suburban New Jersey. He likes playing on his computer, making books that he illustrates himself, and drawing in coloured chalk on his parents' front drive.
Joey also has violent tantrums on a daily basis, which often involve him hitting himself, punching holes in the walls all through the house, and assaulting his mother, leaving her bruised and shaken.
Joey has been diagnosed with autism.
People with autism vary widely in terms of their symptoms. Some are above average intellectually, though many are below average and struggle in mainstream schools.
Commonly, people on the autistic spectrum have trouble with social interaction - using speech, recognising emotions (their own and other people's), body language. They also often have repetitive behaviours and routines and can appear locked in their own worlds.
For reasons that aren't fully understood, diagnosis rates for autism have gone steadily upward in America in recent years. New Jersey is at the forefront of the trend. Latest figures put the autism rates among boys in New Jersey at one in 29 (rates for girls tend to be much lower).
Despite its increasing levels of diagnosis, autism is still poorly understood. Indeed, it is not clear if the real rates of autism are climbing. Some say there are more cases due to improved detection, or, some believe, an overly expanded set of criteria.
In the popular mind, the condition is forever linked to the Dustin Hoffman character in Rain Man, an autistic savant whose idiosyncratic behaviour - obsessive routines, strange vocal mannerisms - was offset by a host of "savant" abilities. He could memorise a phone book and beat the casinos in Las Vegas.
In fact, savant abilities are rare among those with autism.
For my part, my interest in the condition stemmed from an interest in the unique nature of the relationship between parents and their diagnosed kids.
Louis Theroux with JoeyParents of autistic children can find it a struggle to cope
Raising a child on the autistic spectrum presents a very demanding, though often rewarding, set of challenges.
As a father of two young boys, who are in psychiatric parlance "neuro-typical", I know first-hand how hard it can be when your four-year-old refuses to eat his vegetables or goes through weird phases of waking every few hours; the tantrums over certain clothes and the squabbles over who was playing with what first.
But raising a child with autism puts my stresses in the shade.
Carol has a cot next to Joey's bed where she sleeps most nights, to stop him getting out of bed and wandering around.
Children with autism sometimes sleep erratically into their teens. In terms of sleepless nights, many parents of diagnosed children remain in a kind of "newborn" mode for 10 or 15 years.
Language can develop incredibly slowly, or barely at all. Even sometimes, when the communication skills are there, an autistic child may seem to have no interest in communicating.
There can also be tantrums and outbursts.
It's not always clear what is causing a tantrum. It might be that a kid's playtime has been refused or brought to an end, but it might be something more obscure - a thought or a memory.
Nor is it always clear how best to handle a tantrum once it's started. When I first met them, Carol would lie on top of Joey to stop him from smashing up the place, sometimes in tandem with her husband Tadeo who would pin down his legs.
    A few weeks later, she implemented a new regime of giving him boxing gloves to soften his self-inflicted blows and keeping him in his room until the tantrum had blown over.
    As a TV presenter, the subject of autism also put me in a tricky position. I had to figure out how to get to know children, some of whom could only speak a handful of words, and whose way of interacting socially was very different to the ones I was used to.
    But this, in a way, was the point - that I should get a little glimpse of the strains, and the pleasures, of having a relationship with someone diagnosed with autism.
    On the positive side, kids on the spectrum can make massive strides in their progress, in rare cases losing the diagnosis entirely.
    With its high rates of autism, New Jersey is home to some of America's best services, including a remarkable school, the Developmental Learning Center in Warren, NJ. The DLC Warren lavishes resources on the 250 or so kids who go there, almost all of them diagnosed with autism. The teacher/student ratio is about 1/1.5.
    One of the children I met, Nicky Ingrassia, had been non-verbal until the age of six, and yet was now highly articulate, not to mention curious and humorous. Nicky had progressed to the point that he was being moved to a more mainstream school.
    But Nicky's level of progress is not the rule.
    Nicky Ingrassia turns the tables on Louis Theroux
    Just as typical was the story of the Englehard family.
    Josephine Englehard's son Brian was eight when he burned down the family house. As he grew older, he began assaulting Josephine, often when she refused him certain items of food. Sometimes he chased her around the house and pulled her hair out in clumps.
    After one particularly violent incident Josephine called the police. Brian was sent to a psychiatric hospital. From there, he moved to a group home where he still lives, aged 20.
    Brian spends Saturday and Sunday back in the family home. One Saturday I went with Josephine as she picked him up. Having heard so much about Brian's tantrums, I was a little nervous about meeting him.
    But over the course of the afternoon, using body language and a little bit of speech, Brian and I seemed to strike up a bit of a rapport. I found Brian outgoing, mischievous, and - especially after everything I'd heard about autism - surprisingly interested in me.
    Josephine told me that, although it had been a huge wrench moving Brian out of the house, he was now much calmer and seemingly much happier - a change she partly put down to the effect of the correct use of psychiatric medication.
    Sure enough, by the end of the visit, in the early evening, it was Brian who volunteered that he wanted to go back. In the car on the drive to the home, we listened to some merengue music on a Latin radio station, and the two of us grooved together sedately in the backseat.
    Joey's future remains uncertain.
    Carol says she is praying for a miracle for him, that he will somehow emerge from his autism.
    At the moment he is not on medication. Should his behaviour become even more disruptive as he gets bigger, Carol has resolved to try drugs as a first resort. If this doesn't help, a move to a group home like Brian's is not out of the question.
    In the end, I came away from my trip in New Jersey impressed, more than anything else, by the patience and love shown by the parents of the autistic children.
    The demands made of parents whose children are diagnosed with autism can be immense.
    Though Carol was praying for a miracle, in the course of spending time with her I felt she was performing a small miracle of her own simply by keeping going.
    An earlier version of this story incorrectly gave the ratio of teachers to students at DLC Warren as 1.5:1. The correct ratio is 1:1.5.
    Here is a selection of your comments.
    I feel for the parents, but especially I feel for the children. I have Asperger's Syndrome but was not diagnosed until I was well into my 50s. Growing up whilst rarely fitting in was hell. Increasing the awareness of the problems associated with autism needs to be handled carefully, many Aspies are not violent, just bewildered.
    Malcolm Midgley, Papamoa Beach, New Zealand
    So often autism is depicted as something where people are just a little strange but have huge abilities . In the majority of cases - and certainly amongst the parents of autistic children we know - it's more like having a 3-year-old in a 15-year-old's body . Life is difficult , sometimes violent and always stressful . Our son was an escapee - he would try and escape from the house and just run. Our house was like fort knox but he still got out. The last time he fell from the roof and broke his hip. Not exactly Rain Man is it ?
    Peter Little, Herne Bay
    My daughter was diagnosed at the age of two-and-a-half years old. Her speech came at the age of four, she could not pick up a pencil till the age of five. Presently she is studying at a normal school. She scores 80% to 90% marks in studies. She can understand everything. But her speech is not constructive. She cannot think in a different way. She is always withdrawn in nature.
    P P Pal, Uttarpara, West Bengal, India
    We are parents of three lovely, gorgeous boys. Our seven year-old is severely autistic and non-verbal but we all know that our efforts are worth it when we get a little bit of eye contact or a little smile or, on a really good day, a quick hug. The world can be a scary place for him, not knowing what to expect or what to do or how to act. But sometimes if you catch him really looking at something whether it's a flower or a ladybird or the leaves blowing in the wind - sometimes - it's good to look at things through his eyes. You realise that instead of rushing around just stop and really look at something and appreciate its beauty or its strangeness.
    Janis Cuthbert, Dunfermline
    As a perfectly verbal and expressive individual, I would like journalists to recognize that I AM on the spectrum. That the spectrum does not go from "genius, gifted, tragic, bit weird," to "sociopath, can't communicate,". It is a spectrum. We are as varied - and more so - than you could ever imagine. But no one wants to read stories of boring autistic people. I'm boring. I'm 22, I live at home with my family, I'm going to uni (again!) next year to do an arts subject, I have mates, I have hobbies, it's my fourth anniversary with my partner in June, and I don't hit people.
    Dee, Belfast
    My son was diagnosed with Aspergers Syndrome, but was badly misunderstood at school, with very distressing consequences. Anyway, he was so unhappy and home life was suffering to such an extent that we sent him to a private school. He loved it for a time and went to the top of his class until a teacher came along who wasn't so sympathetic. Again, we had the same problems so we took the monumental decision to take him out of school and have him home educated. Twelve years later, my son is at a top university studying physics with maths, two hundred miles away. He plays music in lots of groups and manages himself in the student accomodation without any support.

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