Tuesday, 20 November 2012

Great apes may have 'mid-life crisis', a study suggests


Great apes may have 'mid-life crisis', a study suggests


Portrait of a chimpanzeeDo chimpanzees experience a midlife low in happiness?

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Chimpanzees and orangutans may experience a "mid-life crisis" like humans, a study suggests.
An international team of researchers assessed the well-being and happiness of the great apes.
They found well-being was high in youth, fell to a low in midlife and rose again in old age, similar to the "U-shape curve" of happiness in humans.
The study brought together experts such as psychologists, primatologists and economists.
Results are published in the Proceedings of the National Academy of Sciences.
"What we are testing is whether the U-shaped curve can describe the association between age and well-being in non-human primates as it does in humans," psychologist and lead author Dr Alexander Weiss of the University of Edinburgh told BBC Nature.
Dr Weiss hoped the results would show a similar curve because of the close relationship between humans, chimpanzees and orangutans.

Close relatives

Chimpanzee looking forward
The study showed that male and female humans, chimpanzees and orangutans have the same U-shaped curve despite differences in social roles, and the phenomenon is therefore not uniquely human.
Testing times
The sample subjects included 508 chimpanzees (Pan troglodytes) and orangutans (Pongo sp.) of varying ages, from zoos, sanctuaries and research centres.
They were assessed by zoo keepers, volunteers, researchers and caretakers who had worked with the primate subject for at least two years and knew its behaviour.
The animals were numerically scored for well-being and happiness on a short questionnaire, which was based on a human well-being model but modified for use in non-human primates.
Dr Weiss said that the similarities between humans, chimps and orangutans go beyond genetics and physiology.

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It was quite mind-blowing... to find it in apes”
Prof Andrew OswaldEconomist
For example, chimpanzees face similar social pressures and stress factors to humans.
"You don't have the chimpanzee hitting mid-life and suddenly they want a bright red sports car," explained Dr Weiss.
"But there may be other things that they want like mating with more females or gaining access to more resources."
Co-author Andrew Oswald, professor of economics at the University of Warwick, has researched human happiness for 20 years.
"One of the reasons we decided to look at ape data was that when you study humans, that U-shape is exactly the same when you adjust statistically for things like education, income and marriage.
For Prof Oswald it was "quite mind-blowing... to find it in apes".
Bornean orangutan with hand on headThe study showed that orangutans may experience a midlife dip in well-being and happiness
He concluded that "the mid-life crisis is real and it exists in... our closest biological relatives, suggesting that it is probably explained by biology and physiology".
The bigger picture
Psychologist Dr Weiss said that this research opens a lot of doors.
He explained that for a long time this kind of mid-life crisis was considered something specific to human society and human lives.
"And what [this study] says is that it may be a part of the picture, but it's clearly not all of the picture.
"We have to look deeper into our evolutionary past and that of the common ancestors that we share with chimpanzees, orangutans and other apes."
Join BBC Nature on Facebook and Twitter @BBCNature.

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Sunday, 18 November 2012

Fears over health and loneliness of elderly this winter


Fears over health and loneliness of elderly this winter

Elderly womanPensioners could suffer alone this winter

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People are being asked to call in on their elderly neighbours this winter amid fears pensioners will suffer worse than ever.
Age UK estimates that as many as 25,000 older people could die needlessly because of the cold.
It says the drop in temperature could see an increase in health problems for older people and risk leaving them isolated in their own homes.
The charity surveyed more than 1,000 adults aged over 65 across the UK.
The responses suggest that 3.5 million people in this age group in the UK are not getting any help or support from their neighbours.
Some 7% of them do not know their neighbours at all, the survey found.
Age UK's research also found that 35% were concerned about keeping warm at home during the winter.
Health risks
The over-65s contacted were concerned about not getting out during the shorter days and worried about falling over on slippery pavements and injuring themselves.

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The winter can cause misery, avoidable illness and even death for too many older people”
Michelle MitchellAge UK
More than 21% said they were worried about being stranded at home.
Previous research shows that cold weather can increase the risk of health problems in older people, including heart attacks and strokes, respiratory problems, pneumonia and depression.
Feeling isolated and lonely is also known to have an impact on physical and mental health.
Michelle Mitchell, charity director general of Age UK, said winter was a difficult time.
"The winter can cause misery, avoidable illness and even death for too many older people.
"We're hoping to inspire everyone to act now to do their bit to lessen the impact of winter for older people this year.
"There is something simple that everyone can do from popping in to check on an older neighbour to making time for older relatives."

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Wednesday, 14 November 2012

DNA sequencing of MRSA


DNA sequencing of MRSA used to stop outbreak

MRSA

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An outbreak of the hospital superbug MRSA has been brought to an end by UK doctors cracking the bacterium's genetic code.
It led to them finding one member of staff at Rosie Hospital, in Cambridge, who may have unwittingly carried and spread the infection.
They say it is the first time rapid genetic testing has been used to track and then stop an outbreak.
One expert said this would soon become "standard practice" in hospitals.
Doctors were concerned after MRSA was detected in 12 babies during routing screening.

MRSA

MRSA - or methicillin-resistant staphylococcus aureus - is a bacterial infection that is resistant to a number of widely-used antibiotics.
People can carry the bug without health problems and it is spread by skin-to-skin contact or through contaminated objects such as bedding.
It can cause life-threatening infections if the bug breaches the skin, such as through a surgical wound.
However, current tests could not tell if it was one single outbreak being spread around the unit or if they were separate cases being brought into the hospital. About one in 100 people carry MRSA on their skin without any health problems.
To find out, researchers at the University of Cambridge and the Sanger Institute embarked on more sophisticated version of a paternity test.
They compared the entire genetic code of MRSA bugs from each baby to build a family tree. It showed they were all closely related and part of the same outbreak.
After two months without a case and deep cleaning the ward, another case appeared. Analysing the DNA showed that it was again part of the outbreak and attention turned to a carrier.
Tests on 154 members of staff showed that one was also carrying MRSA, which may have been spread to babies in the unit. They were treated to remove the infection.
"We believe this brought the outbreak to a close," said Dr Julian Parkhill, from the Sanger Institute.
"This is really exciting for us because it gave the hospital the opportunity to intervene.
"We think this is the first case where whole genome sequencing has actually led to a clinical intervention and brought the outbreak to a close."
Bacterial DNABacterial DNA was analysed
The study was published in the medical journal Lancet Infectious Diseases.
Cheaper
The cost of working out the entire genetic code of a bacterium has plummeted from millions of pounds to about £50.
The time it takes has also fallen dramatically from months to hours.
Dr Parkhill said it could get even cheaper: "People are talking about the thousand dollar human genome.
"If you can do the human genome for a thousand dollars you can do a bacterial genome for one dollar."
Commenting on the research Prof Ross Fitzgerald, from the Roslin Institute at the University of Edinburgh, told the BBC: "The study clearly highlights the power of whole genome sequencing for resolving the source and the spread of an epidemic of hospital acquired infection such as MRSA.
"It will ultimately, within a small number of years, be standard practice for any hospital outbreak.
"I fully expect this to be rolled out as a standard approach in UK hospitals in the very near future."
Prof Sharon Peacock, from the University of Cambridge, said she wanted to develop a simple system that could be used easily by hospitals.
She said she envisioned a "black box" where the genetic sequence goes in and a simple report that can be used by hospital staff comes out.
"It could, for example, determine the species of the bacterium; it could determine antibiotic susceptibility, and it could provide information about what genes are present that are often associated with poor outcomes in patients."
Sir Mark Walport, director of the Wellcome Trust, said: "This is a dramatic demonstration that medical genomics is no longer a technology of the future - it is a technology of the here and now."

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overhaul is needed in the system for caring for people


'Catastrophic failings' in schizophrenia care

Nurse and patientAlternative ways of caring for patients with schizophrenia are needed, says the inquiry

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An independent inquiry says a major overhaul is needed in the system for caring for people with schizophrenia.
The Schizophrenia Commission, which was set up a year ago, says patients spend too long in "demoralised and dysfunctional" hospital wards.
Its analysis suggests the condition costs society almost £12bn a year - and treatment budgets could be spent more wisely to stop people from getting ill.
The government says mental health is one of its high priorities.
A spokesman said: "We are clear that people with mental health problems should be treated with the same high quality and dignified care as anyone else and we expect the NHS to make this happen."
The commission, which was established by the charity Rethink Mental Illness, says too much is spent on secure care - 19% of the mental health budget in England last year - with many people staying too long in expensive units.
Among the 42 recommendations, the report calls for a better use of "recovery houses" in the community, to provide an alternative to hospital admission.

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It is a scandal that in 2012 people with schizophrenia are dying 15-20 years earlier than the general population”
Paul JenkinsRethink Mental Illness
The average cost of a night in a mental health in-patient bed is £321 - meaning a typical admission of 38 days costing more than £12,000.
The commission says early intervention teams, which aim to help people before their hallucinations or delusions become severe, are popular and should be extended. The report claims some teams are being cut or diluted at the moment.
'Madhouse'
Prof Sir Robin Murray from King's College London, which chaired the commission, said: "If you have psychosis and your mind is disturbed, you need a period of respite and calm.
"But especially in inner cities, you get admitted to something like a madhouse. The nurses are often overwhelmed.
"If patients have had a bad experience and then a further relapse, it's more likely they will then have to be admitted by compulsion.
"The system is pervaded by pressure. People are locked up too often and for too long.
"There's a preoccupation with risk, and the idea that this is a madman with an axe. But people with schizophrenia are actually more likely to be attacked themselves.

Recovery

Dan Lowe, 36, began having psychotic symptoms 16 years ago.
He has been admitted to hospital four times, each stay lasting several months.
Dan found the stays in hospital sometimes made his paranoia worse.
He is now taking clozapine, a medicine which has helped him a lot.
Dan lives independently in Surrey, with support from a community psychiatric nurse.
He enjoys taking part in a regular computer course.
"There's no other condition where such an emphasis is put on the risk of an effect on other people."
The report says care of people with schizophrenia and psychosis is falling "catastrophically short".
An economic analysis for the commission highlighted an "exceptionally low" employment rate for people with schizophrenia of 7%, as well as disrupted education - because the illness often develops in young adulthood.
The authors said some of the costs of schizophrenia were unavoidable - but effective interventions, such as family therapy and making a concerted effort to find people jobs, were not being widely used.
Paul Jenkins, head of the charity Rethink Mental Illness, was also a member of the commission.
He said: "It's been over 100 years since the term 'schizophrenia' was first coined, but care and treatment are still nowhere near good enough.
"It is a scandal that in 2012 people with schizophrenia are dying 15-20 years earlier than the general population."
The report said tackling those worse chances of physical ill health would take many years, but made economic sense.
And it highlighted poor prescribing practice as another problem faced by people with schizophrenia, saying patients were not always receiving the most effective medication.
The report - titled The Abandoned Illness - concludes patients can be given hope and support, with the aim of stability or recovery.

Sunday, 4 November 2012

Liverpool Care Pathway: Relatives 'must be informed


Liverpool Care Pathway: Relatives 'must be informed'Elderly man's hands

There will be a 12-week consultation on the proposed changes to the NHS constitution

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Relatives of terminally-ill patients would have to be consulted before a decision to withdraw food or water is taken, under new government proposals.
It comes after some patients were placed on the Liverpool Care Pathway - designed to relieve suffering - without their relatives' knowledge.
The government wants to ensure families are told of life and death decisions.
The instruction will be included in a number of proposed changes to the NHS Constitution to be unveiled on Monday.
The Liverpool Care Pathway was developed at the Royal Liverpool University Hospital and the city's Marie Curie hospice to relieve suffering in dying patients, setting out principles for their treatment in their final days and hours.
Supporters say it can make the end of a patient's life as comfortable as possible and the method is also widely backed by doctors and many health charities.
However, critics argue it can be inhumane.
The government has now said that the rules needed to be stricter, meaning relatives of patients are always consulted before the technique is applied.
'New right'
A Department of Health (DoH) spokesman said the proposed changes would set out a "new right" under the NHS Constitution, which was established by the Health Act 2009, but he stopped short of describing the move as a "legal requirement".
However, the spokesman added: "Anybody providing NHS services is required by law to take account of it [the NHS constitution] in their decisions and actions."
Some reports suggested health trusts that failed to involve patients and families in decisions could be sued, while doctors could face being struck off.
The DoH spokesman said it was unlikely policy had been developed on this as the proposal was still at an early stage.
Health Secretary Jeremy Hunt will launch a 12-week consultation on the proposed changes to the constitution - the formal statement of patients' rights - on Monday.
Health minister Norman Lamb said this week that it was "completely wrong" for terminally-ill patients to be put on a "pathway" to death without relatives being consulted.
Mr Lamb has called a meeting of doctors and patients to discuss worries about the pathway.
Meanwhile, Conservative peer Baroness Knight called for an inquiry into claims some people might have survived had they not received this treatment.

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