Monday, 13 September 2010

EU tightens rules on welfare of lab animals

EU tightens rules on welfare of lab animals

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MEPs approved new rules on animal welfare in lab experiments

The EU has agreed on new rules aimed at reducing the number of animals used in lab experiments and tightening controls over such procedures.

Euro MPs backed the new EU directive after long negotiations and EU member states have two years to make it law.

Labs will have to get approval from national authorities for animal tests and if recognised alternatives exist then they must be used, the rules say.

Animal welfare groups say the directive still does not go far enough.

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The UK-based anti-vivisection group BUAV called it "a missed opportunity".

"The dropped proposals include strong restrictions on the use of non-human primates, strong restrictions on re-using individual animals, and a clear ban on experiments which involve severe and prolonged suffering," it said.

But BUAV said it was "pleased, however, that the [European] Commission has clarified that non-animal alternatives have to be used wherever they are scientifically suitable".

The new directive, approved by the European Parliament on Wednesday, replaces EU rules on animal testing that dated back to 1986.

Lab mice - file pic The new animal welfare standards will have to be embraced by all EU member states

Now the new member states - mainly in Central and Eastern Europe - that joined the EU in 2004 and 2007, will have to embrace the new animal welfare standards.

The legislation imposes a general ban on the use of great apes, such as chimpanzees and gorillas, in scientific tests. But other primates such as macaques can still be used - a point on which the Commission was overruled by MEPs.

Measuring pain

The directive also sets out categories of pain, ranging from "mild" to "severe" - an innovation designed to prevent repeated suffering.

The re-use of animals will be allowed after tests involving "moderate" pain - though the Commission had proposed re-use only after tests classed as "up to mild" pain.

MEPs argued that re-use of animals helped reduce the total number of animals used. They were also concerned that Europe should not fall behind in research on chronic human ailments such as Alzheimer's.

According to EU data, about 12 million animals are used in EU countries' lab experiments each year.

The directive obliges national authorities to carry out regular inspections of labs that use animals - and some of the visits must be unannounced. The Commission will oversee these checks.

The animal protection group Humane Society International said the new directive would still not prevent "severe suffering" in certain types of animal testing.

But it voiced hope that other countries, including the US, would now "follow Europe's lead so that standards are improved globally".

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Botox industry register launched

Botox industry register launched

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Former beauty clinic manager Sarah Payne recalls how a dermal filler treatment went badly wrong

A government-backed register for providers of injectable cosmetic treatments such as botox and dermal fillers has been launched.

Those who meet the standards set down for the Independent Heathcare Advisory Services' voluntary register, will receive a quality assurance mark.

The IHAS hopes people will be steered away from "botox parties" or treatments offered in inappropriate locations.

But cosmetic surgeons say such self regulation will not stop bad practice.

Botox boom

The introduction of the register comes amid a boom in demand for botox and dermal fillers.

According to the IHAS, there are currently about 5,000 providers of injectables in the UK, carrying out about 200,000 treatments each year.

Other estimates suggest far higher numbers of people in the UK are seeking out these treatments.

Start Quote

Self-regulation hasn't worked in the Houses of Parliament has it, and it hasn't worked in the banking industry, so why would it work in cosmetic medicine?”

End Quote Nigel Mercer British Association of Aesthetic Plastic Surgeons

But there are growing concerns over people receiving treatments in inappropriate settings.

"We've heard stories of botox parties and people going to even garden sheds [to have treatment], " IHAS director Sally Taber said.

"It's just amazing that the general public think that they can have an injection into their face in a nail bar, a garden shed or at a botox party, because you are dealing with a prescription medicine.

"They can cause permanent damage. The patient will be reminded all their lives that they've gone to an inappropriate practitioner who wasn't appropriately qualified," she warns.

No beauticians

The new register of injectable cosmetic providers represents an attempt by the injectables industry to regulate itself.

It will be funded by the treatment providers who must pay registration and annual fees to join.

Those signing up to the register must promise that all prospective clients receive a face-face consultation before any treatment goes ahead.

They must also ensure that procedures takes place in a clean and safe clinical setting and registered premises may be inspected at random by an outside agency.

Those injecting must also have the right training, with only doctors, dentists and registered nurses eligible.

INJECTABLE

A bottle of botox
  • Botox is a trade name for a protein produced by the bacterium Clostridium botulinum and is highly toxic
  • In small doses, Botox works by temporarily paralysing the muscles of the face which are used in frowning and raising the eyebrows
  • In larger doses, Botox can leave the face with a lack of expression
  • Dermal fillers are usually used in the lower face to "fill" in wrinkle lines and folds and to pump up cheeks and lips
  • Non-permanent dermal fillers include bovine (cow) collagen and products based on hyaluronic acid
  • Other injectable gels such as Macrolane are used to augment breasts and buttocks

"Occasionally a patient could have an anaphylactic shock when the patient has a reaction to the medicine and collapses and may need a tube down their throat to ensure their airway is sufficient for them to breath again," Ms Taber said.

"We don't feel that it is appropriate for a beauty therapist to have that kind of responsibility."

The new scheme has already come under heavy criticism from plastic surgeons. A recent poll among members of the British Association of Aesthetic Plastic Surgeons found only 4% would consider signing up.

The organisation's outgoing president Nigel Mercer says the scheme is more about clinics marketing their services than protecting the consumer.

"Self-regulation hasn't worked in the Houses of Parliament has it, and it hasn't worked in the banking industry, so why would it work in cosmetic medicine?" he said.

"Self-regulation effectively means it's a free for all.

"What we've been suggesting is something like 'Ofcos'. Obviously quangos are not the order of the day at the moment, but there really is public harm being done."

He also points to new European regulations that are currently under consideration, which he says, offer a more robust alternative.

Ms Taber believes such is the cost-cutting climate of the moment, that external regulation is off the agenda.

"All of the industry wanted regulation to begin with," she said, "but it's obvious from the previous government and now the coalition government, that has given this scheme its support, that we're not going to get it.

"A set of professionally led standards at the moment is the correct way forward."

Trout pout

Botox works by temporarily paralysing nerves in the upper face to reduce wrinkling when people smile or frown.

Dermal fillers, such as hyaluronic acid, are used largely on the lower face to fill in creases and wrinkles. They can also be used to pump up cheeks and produce a lip "pout".

Some of these fillers offer temporary solutions, others are semi-permanent or permanent.

But while many are turning to these treatments, there are undoubted risks.

Michael Saul of Manchester-based solicitors TJL specialises in representing victims of substandard cosmetic surgery and injectable treatments.

"You find a whole raft of problems following these treatments. There's asymmetry if they are not injected correctly, you can have lumps and nodules which look extremely unsightly in prominent areas of the face. There are problems with infection and terrible allergic reactions."

He also has a case where the injected product migrated under the skin.

"The dermal filler has migrated from the nasolabial fold into the eye orbit and is causing problems with vision. It's going to be very difficult and dangerous to remove it from the eye orbit and it carries a risk of blindness."

He too favours external regulation. "This industry is very profitable for practitioners and inadequately regulated and that's a very dangerous mix," he said.

He believes those who speak out or seek out legal representation represent only "the tip of the iceberg".

"A lot of people don't know where to run if they have problems so don't do anything. If something goes wrong after an aesthetic procedure, a common psychological reaction for people is to blame themselves. A lot of people want to lock themselves away."

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Friday, 10 September 2010

Halley's comet 'was spotted by the ancient Greeks'

Halley's comet 'was spotted by the ancient Greeks'


Halley's comet may have been visible from Earth in 466BC, say the researchers
A celestial event seen by the ancient Greeks may be the earliest sighting of Halley's comet, new evidence suggests.
According to ancient writers, a large meteorite smacked into northern Greece between 466BC and 467BC.
Halley's comet (SPL)The writers also described a comet in the sky at the time the meteorite fell to Earth, but this detail has received little attention, say the researchers.
Comet Halley would have been visible for about 80 days in 466BC, researchers write in the Journal of Cosmology.
New Scientist magazine reports that, until now, the earliest probable sighting of the comet was an orbit in 240BC, an event recorded by Chinese astronomers.
If the new findings are confirmed, the researchers will have pushed back the date of the first observation of Comet Halley by 226 years.
The latest idea is based on accounts by ancient authors and concerns a meteorite that is said to have landed in the Hellespont region of northern Greece in 466-467BC.
The space rock fell during daylight hours and was about the size of "a wagon load", according to ancient sources.
The object, described as having a "burnt colour", became a tourist attraction for more than 500 years.
Look west
In his work Meteorology, Aristotle wrote about the event about a century after it occurred. He said that around the same time the meteorite fell, "a comet was visible in the west".
Astronomer Eric Hintz and philosopher Daniel Graham, both of Brigham Young University in Provo, Utah, reconstructed the likely path of Halley's comet, to see whether it agreed with the ancient observations.
They calculated that Halley's comet could have been visible for about 80 days between early June and late August in 466BC - depending on atmospheric conditions and the darkness of the sky.
"It's tough going back that far in time. It's not like an eclipse, which is really predictable," co-author Eric Hintz, from Brigham Young University in Provo, Utah, told BBC News.
"But we feel fairly good about this. If the [sighting] in 240BC is accepted, this has a fairly solid possibility."
He added: "If accepted, this would be three orbits earlier [than the Chinese sighting]."
Halley's Comet on the Bayeux Tapestry (Getty) In the 11th Century, Halley's Comet was depicted on the Bayeux Tapestry
The reconstruction of the comet's path agrees with the ancient reports, which say the comet was visible for about 75 days.
The researchers point out that while the Chinese and Babylonians kept meticulous records of heavenly phenomena for centuries, the ancient Greeks did not.
Nevertheless, the Greek accounts do provide important information, say Graham and Hintz, such as the comet's period of visibility from Earth.
Asked whether it was possible that the meteorite fall and the pass by Halley's Comet could be linked, Dr Hintz was doubtful.
"it would be really neat if they were connected - if it was a piece of Halley's that fell. My feeling is that it was just a really cool coincidence," said Dr Hintz.
The researchers say that there remains the possibility that other ancient sightings of comets could be uncovered from Chinese and Babylonian records.

Thursday, 9 September 2010

Astronomers find evidence for unusual class of black holes

Astronomers find evidence for unusual class of black holes


An artist's impression of the source HLX-1 - the light blue object to the top left of the galactic bulge
Researchers say they may have found further evidence for the existence of an unusual type of black hole.
Using the European Southern Observatory's Very Large Telescope (VLT) in Chile, an international team of scientists studied the images of the most extreme ultra-luminous X-ray source, HLX-1.
An artist's impression of the source HLX-1They say the data about the distance and the brightness of the source shows that it may contain an intermediate-size mass black hole, located some 300 million light years away from Earth.
The results of the study have been published in the Astrophysical Journal.
A black hole is a region of space that has such an extremely powerful gravitational field that it absorbs all the light that passes near it and reflects none.
If confirmed, HLX-1 would be classified as an intermediate-type black hole - something astrophysicists suspected to exist, but for which there have been only tentative detections in the past.
Radiation question
The lead author Klaas Wiersema of the University of Leicester's department of Physics and Astronomy, said that after the earlier discovery of the very bright X-ray source, the astronomers "were very keen to find out just how far away it really is, so that we can work out how much radiation this black hole produces".
Understanding how super-massive black holes form... is crucial to our comprehension of the formation of galaxies”
End Quote Sean Farrell University of Leicester
"We could see on images taken with big telescopes that a faint optical source was present at the location of the X-ray source, located near the core of a large and bright galaxy," he said.
"We suspected that this faint optical source was directly associated with the X-ray source, but to be sure we had to study the light of this source in detail, using the Very Large Telescope in Chile."
He said that the VLT was able to measure the precise distance to HLX-1 and the data from the telescope allowed the scientists to separate the light of the big, bright galaxy from that of the faint optical source.
"Much to our delight we saw in the resulting measurements exactly what we were hoping for: the characteristic light of hydrogen atoms was detected allowing us to accurately measure the distance to this object.
"This provided conclusive proof that the black hole was indeed located inside the big, bright galaxy, and that HLX-1 is the brightest ultra-luminous X-ray source known."
Galactic centre
HLX-1 is located in another galaxy some 300 million light years from our planet. The study also shows that the source is not a super-massive black hole.
An artist's impression of a black hole at the centre of a galaxy An artist's impression of a black hole at the centre of a galaxy
Astronomers believe that the centres of most galaxies contain such super-massive black holes, and intermediate black holes might simply turn out to be their progenitors.
"Understanding how super-massive black holes form and grow is thus crucial to our comprehension of the formation and evolution of galaxies, which in turn goes part of the way to answering one of the really big questions: how did our own galaxy form and evolve?" said astronomer Sean Farrell, also of the University of Leicester.

Astronomers find evidence for unusual class of black holes

Astronomers find evidence for unusual class of black holes

An artist's impression of the source HLX-1 An artist's impression of the source HLX-1 - the light blue object to the top left of the galactic bulge

Researchers say they may have found further evidence for the existence of an unusual type of black hole.

Using the European Southern Observatory's Very Large Telescope (VLT) in Chile, an international team of scientists studied the images of the most extreme ultra-luminous X-ray source, HLX-1.

They say the data about the distance and the brightness of the source shows that it may contain an intermediate-size mass black hole, located some 300 million light years away from Earth.

The results of the study have been published in the Astrophysical Journal.

A black hole is a region of space that has such an extremely powerful gravitational field that it absorbs all the light that passes near it and reflects none.

If confirmed, HLX-1 would be classified as an intermediate-type black hole - something astrophysicists suspected to exist, but for which there have been only tentative detections in the past.

Radiation question

The lead author Klaas Wiersema of the University of Leicester's department of Physics and Astronomy, said that after the earlier discovery of the very bright X-ray source, the astronomers "were very keen to find out just how far away it really is, so that we can work out how much radiation this black hole produces".

Start Quote

Understanding how super-massive black holes form... is crucial to our comprehension of the formation of galaxies”

End Quote Sean Farrell University of Leicester

"We could see on images taken with big telescopes that a faint optical source was present at the location of the X-ray source, located near the core of a large and bright galaxy," he said.

"We suspected that this faint optical source was directly associated with the X-ray source, but to be sure we had to study the light of this source in detail, using the Very Large Telescope in Chile."

He said that the VLT was able to measure the precise distance to HLX-1 and the data from the telescope allowed the scientists to separate the light of the big, bright galaxy from that of the faint optical source.

"Much to our delight we saw in the resulting measurements exactly what we were hoping for: the characteristic light of hydrogen atoms was detected allowing us to accurately measure the distance to this object.

"This provided conclusive proof that the black hole was indeed located inside the big, bright galaxy, and that HLX-1 is the brightest ultra-luminous X-ray source known."

Galactic centre

HLX-1 is located in another galaxy some 300 million light years from our planet. The study also shows that the source is not a super-massive black hole.

An artist's impression of a black hole at the centre of a galaxy An artist's impression of a black hole at the centre of a galaxy

Astronomers believe that the centres of most galaxies contain such super-massive black holes, and intermediate black holes might simply turn out to be their progenitors.

"Understanding how super-massive black holes form and grow is thus crucial to our comprehension of the formation and evolution of galaxies, which in turn goes part of the way to answering one of the really big questions: how did our own galaxy form and evolve?" said astronomer Sean Farrell, also of the University of Leicester.

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Vitamin B 'puts off Alzheimer's'


Vitamin B 'puts off Alzheimer's'



CT scan Brain scan of a person with Alzheimer's
A new study suggests high doses of B vitamins may halve the rate of brain shrinkage in older people experiencing some of the warning signs of Alzheimer's disease.
Brain shrinkage is one of the symptoms of mild cognitive impairment, which often leads to dementia.
Researchers say this could be the first step towards finding a way to delay the onset of Alzheimer's.
Experts said the findings were important but more research was needed.
The study, published in the journal Public Library of Science One, looked at 168 elderly people experiencing levels of mental decline known as mild cognitive impairment.
This condition, marked by mild memory lapses and language problems, is beyond what can be explained by normal ageing and can be a precursor to Alzheimer's and other forms of dementia.
Half of the volunteers were given a daily tablet containing levels of the B vitamins folate, B6 and B12 well above the recommended daily amount. The other half were given a placebo.
After two years, the rate at which their brains had shrunk was measured.
The average brain shrinks at a rate of 0.5% a year after the age of 60. The brains of those with mild cognitive impairment shrink twice as fast. Alzheimer's patients have brain shrinkage of 2.5% a year.
The team, from the Oxford Project to investigate Memory and Ageing (Optima), found that on average, in those taking vitamin supplements, brain shrinkage slowed by 30%.
In some cases it slowed by more than 50%, making their brain atrophy no worse than that of people without cognitive impairment.
'Protecting' the brain
Certain B vitamins - folic acid, vitamin B6 and B12 - control levels of a substance known as homocysteine in the blood. High levels of homocysteine are associated with faster brain shrinkage and Alzheimer's disease.

“Start Quote

These vitamins are doing something to the brain structure - they're protecting it, and that's very important because we need to protect the brain to prevent Alzheimer's”
End Quote Professor David Smith Oxford University
The study authors believe it was the B vitamins' effect on levels of homocysteine that helped slow the rate of brain shrinkage.
The study author, Professor David Smith, said the results were more significant than he had expected.
"It's a bigger effect than anyone could have predicted," he said, "and it's telling us something biological.
"These vitamins are doing something to the brain structure - they're protecting it, and that's very important because we need to protect the brain to prevent Alzheimer's."
He said more research was now needed to see whether high doses of B vitamins actually prevented the development of Alzheimer's in people with mild cognitive impairment.
The Alzheimer's Research Trust, which co-funded the study, also called for further investigation.
"These are very important results, with B vitamins now showing a prospect of protecting some people from Alzheimer's in old age," said chief executive Rebecca Wood.
"The strong findings must inspire an expanded trial to follow people expected to develop Alzheimer's."
B vitamins are found naturally in many foods, including meat, fish, eggs and green vegetables.
Experts are advising against taking higher than recommended levels in the light of these findings.
Chris Kennard, chair of the Medical Research Council's Neurosciences and Mental Health Board, said: "We must be cautious when recommending supplements like vitamin B as there are separate health risks if taken in too high doses.
"Further research is required before we can recommend the supplement as a treatment for neurodegenerative diseases, such as Alzheimer's."

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Tuesday, 7 September 2010

Tony Blair cancels book signing amid protest fears

Tony Blair cancels book signing amid protest fears

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Mr Blair told Daybreak on ITV1 it was "not as if we need" to do signings
Tony Blair has cancelled a planned book signing in London on Wednesday to prevent causing the public and the police "a lot of hassle".
Mr Blair said: "I don't want the public to be inconvenienced by the inevitable hassle caused by protesters."
Eggs and shoes were thrown at the former UK prime minister at a similar event in Dublin at the weekend.
Mr Blair earlier told ITV it was "not as if we need" to do signings to sell copies of his memoirs.
Announcing his decision to scrap the long-planned event, he said: "I know the Metropolitan Police would, as ever, have done a superb job in managing any disruption but I do not wish to impose an extra strain on police resources, simply for a book signing.
"I'm really sorry for those - as ever the majority - who would have come to have their books signed by me in person. I hope they understand."
'Concerned'
Four men were arrested after eggs, bottles and shoes were thrown at him during anti-Iraq war protests at the Dublin signing following the release of his memoirs last week.
Mr Blair described those involved as a "minority", adding that, on such occasions, "the protesters get all the publicity".
Another event had been planned for Waterstone's in Piccadilly, central London, on Wednesday, with rigorous security measures in place.
But ahead of it being cancelled Mr Blair, prime minister from 1997 to 2007, told the ITV breakfast programme Daybreak: "To be frank about it, I am concerned - if people want to have a book signed, people should protest but not try and physically prevent you doing it."
Waterstone's said the signing was cancelled on "the wishes of the author".
Managing director Dominic Myers, said, "Our job as a bookseller is to bring books to our customers, and where possible enable them to meet authors as well.
"It is a matter of regret that because of the likely actions of a minority, our customers are now not able to meet a three-times elected prime minister of the United Kingdom, whose book has become our fastest-selling autobiography ever."
Mr Blair said he would provide signed copies for the store to sell instead.
Lindsey German, convener of the Stop The War Coalition, said the former prime minister "was too frightened to appear at the book signing because he knows that the protests represent widespread opposition to his war-mongering".


Tony Blair: 'Heavy price' for climate inaction

Tony Blair: 'Heavy price' for climate inaction


Mr Blair used the UK's G8 presidency in 2005 to push the issue of climate change
World leaders may pay a heavy price in history if they fail to tackle global warming, Tony Blair has warned.
He said politicians did not have to wait for chaotic climate change in order for them to act.
The risks of not cutting emissions, given the potentially massive consequences, was enough to justify action, he told BBC Radio 4.
Tony Blair (Getty Images)The former prime minister added that it had always been a struggle to explain the uncertainties in climate science.
He told Radio 4's Uncertain Climate documentary: "It's very hard to say 'this is the precise warming there's going to be, this is the maximum amount you can allow this (emissions) to continue'."
He took advice while in 10 Downing Street from the government chief scientist at the time, Professor David King and the President of the Royal Society, Lord May.
"They were very rightly and properly saying there's areas of uncertainty here but if you want a judgement from us as government scientists, then our judgement is this is a serious problem that needs global action to deal with it," he added.
"I was never in the situation of total certainty here and indeed I always used to say to the NGO people (pressure groups) and others (to) be careful you don't end up in a situation where you are claiming that something is certain when it isn't absolutely certain.

"But it doesn't need to be certain for us to act. It just needs to be likely, probable or actually even - if you look at the consequences possible because if you find out 2030 or 2040 'that was a real problem, we should have dealt with that', you're going to pay a pretty heavy price in history."
In the first part of the documentary, broadcast last week, Mr Blair said he did not agree with Gordon Brown or Ed Miliband who called climate sceptics "flat earthers" and "deniers".
He said these were the wrong terms as the science contained uncertainties. He said it was far better to express the issue as one of risk.
The documentary points out that under Mr Blair's tenure as prime minister, emissions in the UK actually rose if embedded emissions from goods imported into the UK were included in the national figures.
The second part of Uncertain Climate will be broadcast on BBC Radio 4 on Monday, 6 September 2010 at 0900 BST and 2130 BST

Monday, 6 September 2010

Diabetes drug still available despite suspension advice

Diabetes drug still available despite suspension advice

Avandia pills GlaxoSmithKline is the world's third largest pharmaceutical company

A drug for type two diabetes is still being prescribed in the UK despite being recommended for withdrawal two months ago, BBC Panorama has found.

Avandia has been linked to a raised risk of heart attacks and heart failure and is under a Europe-wide review.

An expert panel of the UK Medicines and Healthcare products Regulatory Agency (MHRA) said its use should be suspended but it is still available on the NHS.

Manufacturer GlaxoSmithKline (GSK) said it was safe if properly monitored.

'Alternative treatments'

Tens of thousands of patients take Avandia, also known as Rosiglitazone. It was prescribed more than one million times in the UK last year alone.

  • Panorama: A Risk Worth Taking? is broadcast on BBC One, Monday 6 September at 2030 BST or watch again on BBC iPlayer

Pharmaceutical giant GSK said its research programme proved the drug was "safe and effective when it is prescribed appropriately".

Clinicians at the MHRA's advisory body, the Commission on Human Medicines (CHM), voted unanimously in July for Avandia's withdrawal from the UK. But the recommendation was not made public.

The MHRA said following the advice it sent letters to healthcare professionals asking them to "consider alternative treatments where appropriate".

It also said it used the information to push for a UK withdrawal as part of the Europe-wide review by the European Medicines Agency.

The drug is meant to improve life for type two diabetics by helping to regulate blood sugar levels but there is also evidence it could increase the risk of heart failure and heart attacks.

Swelling

"Doctors were advised not to use the tablet in anyone who was at risk of heart failure," said Prof Edwin Gale, a leading UK diabetes expert.

Main types of heart condition

  • A heart attack happens when one of the coronary arteries becomes blocked by a blood clot. This cuts off the supply of blood and oxygen to the heart, causing damage to the heart muscle. This is most likely to happen if you are older, male, a smoker, overweight or have high cholesterol or high blood pressure
  • Heart failure is quite a misleading term and would probably be better called 'heart inefficiency'. It refers to the heart's job as a pump. The heart squeezes a set amount of blood each time it beats. If you have heart failure, the pump is less efficient and cannot cope with squeezing the same amount each time. It does not mean your heart is about to stop at any time - it means it isn't working as well as it should
  • A cardiac arrest is the technical term for when the heart suddenly stops pumping blood around the body. This may be due to an erratic heart rhythm that can sometimes be corrected by defibrillation or 'shocking' the heart.

Source: British Heart Foundation

Prof Gale, who chairs the European Medicines Agency scientific advisory group on diabetes, said Avandia should be withdrawn entirely.

"How long do you wait? How important is it to be absolutely certain and at what point do you start saying - this game isn't worth it, people's lives may be at risk, something should be done about it?" he said.

Clinical pharmacologist Dr Yoon Loke, of the University of East Anglia, said his analysis of the class of drug showed that it doubled the risk of heart failure, regardless of whether or not the patients were considered at high risk before they took the drug.

"Even if you restricted it to patients who don't have heart failure, you will still get patients who newly develop heart failure as a result of Avandia," Dr Loke said.

He has calculated that annually in the UK patients could suffer "about 1,000 extra heart attacks and possibly 600 extra cases of heart failure too as a result of using Avandia".

Launched in Europe 10 years ago, Avandia quickly became the market-leading diabetes tablet, earning GSK billions of pounds.

Usha Patel has diabetes and used the drug to manage her condition. But when she developed painful conditions including swelling in her legs and further tests showed that she had developed heart problems, her GP advised her to stop taking Avandia.

"Because of your heart problems, we don't want you to take any more tablets," her GP told her. "Stop it the next day. Don't take it any more."

'First priority'

Other patients Panorama spoke to have had a more positive experience with their Avandia prescription.

Click to play

US diabetes sufferer Charlene Young said her heart attack "was devastating"

Helen Lovatt was first prescribed the drug by her GP six years ago and thinks that, together with her recent weight loss, it has helped bring her diabetes under control.

"It suits me, doesn't upset me in any way so if it's not broken why mend it?

"I saw in the paper about the possible side effects, but if my doctor's keeping a good check on me, I'm not going to sit and worry about it," she said.

In response to Panorama's findings, GSK said: "Patient safety is our first priority.

"We have carried out an extensive research programme, involving more than 50,000 patients to analyse the safety and benefits of Avandia and continue to believe it is safe and effective when it is prescribed appropriately."

The Europe-wide review by the European Medicines Agency into Avandia will announce findings whether to restrict its prescription or withdraw it completely later this month.

Panorama: A Risk Worth Taking? is broadcast on BBC One, Monday 6 September at 2030 BST.

Saturday, 4 September 2010

Bushmeat is simply meat from wild animals.

Is Africa's wildlife being eaten to extinction?



The rapid growth in the global demand for bushmeat is leaving many African species facing the possibility of being eaten out of existence, says Mark Jones. In this week's Green Room, he calls for western nations to do more to tackle the problem of illegal imports of bushmeat.
Primate bushmeat (Image: Anne-Lise Chaber)
The increasing value of bushmeat has attracted criminal syndicates, with sophisticated and efficient logistical capabilities
We've all heard how the illegal trade in elephant ivory, rhino horn and other high value products is threatening Africa's wildlife.
However, the impact of these products is dwarfed by the trade in bushmeat, defined as meat from Africa's wild animals traded for human consumption.
According to the Bushmeat Crisis Task Force, the hunting of and trade in bushmeat represents "the most significant immediate threat to the future of wildlife in Africa".
Traditionally, bushmeat hunting was a subsistence activity.
It is now a multi-billion dollar international trade involving hundreds of species, from forest herbivores such as duikers and other antelopes to wild pigs, rodents, elephants and primates.
The exponential increase in the trade over recent years is being driven by demand from the exploding and ever more urbanised human population in Africa, and the increasing international value and demand for bushmeat products.
Commercial logging and the associated infrastructure development and expansion have given hunters easy access to previously impenetrable African forests, and ready-made transport routes to towns and cities.
Unsustainable consumption
The term bushmeat is normally used in reference to the illegal trade.
The trade may be illegal because the species concerned is protected under national or international laws, the method of killing is prohibited, or because the animal is taken from a protected area.
The food source was originally exploited because of its low cost, lack of ownership issues, weak law enforcement and the lack of alternatives.
Library picture of a bushmeat market stall in Africa
Bush pigs, duikers, and monkeys for sale at a market in Gabon
Now, the increasing value of bushmeat has attracted criminal syndicates, with sophisticated and efficient logistical capabilities.
Law enforcement agencies in many African countries do not have the resources to keep up, and in some cases high level involvement in the trade may protect it from official interference.
This makes accurate estimates of the trade difficult to obtain, although Central African consumers alone may be eating more than 2.5m tonnes each year.
Many target species have already been extirpated from parts of West Africa. Wildlife in Eastern and Southern African countries is increasingly being targeted, and Kenya is estimated to have experienced a loss of about 50% in its wildlife in recent decades, largely as a result of the bushmeat trade.
A recent study, involving researchers from the Zoological Society of London, estimated that as much as 270 tonnes of bushmeat might be coming through a single airport in Paris annually, destined both for personal consumption and to supply the lucrative trade in high value products.
It is also estimated that more than a quarter of all mammal species hunted for bushmeat are threatened with extinction.
Feeling the loss
Widespread hunting of animals for bushmeat depletes populations of affected species, and can lead to local population crashes or extirpation.
There are, however, much wider potential impacts.
Species have functions: as prey for other species, seed dispersers or forest rebuilders. So reductions in certain species can have far reaching impacts on others, causing a loss of biodiversity and a crisis within ecosystems.
Grasscutter in a cage
Ghanaians started breeding their own bushmeat rather than hunting it
The loss of biodiversity leaves us with a predominance of a few so-called "weedy species", such as those that thrive in continually disturbed, human-dominated environments.
Small populations of highly endangered animals can be disproportionately affected.
Although the number of Great Apes involved in the bushmeat trade is small, their removal can have devastating impacts on populations, and Great Ape species in Africa are thought to be at risk of extinction over the next two decades if the trade continues at its current rate.
The commercial bushmeat trade also threatens the livelihoods and food security of indigenous rural people, which can result in social and political instability.
Bushmeat can also carry potentially devastating diseases - from anthrax to ebola, monkey pox to retroviruses - that may have disastrous impacts on livestock and far-reaching consequences for human health.
Food for thought
For the bushmeat trade to be controlled so that it does not cause further decimation of Africa's wildlife, multi-faceted solutions need urgently to be put in place.
As renowned conservationist Ian Redmond suggests, we need to aim for the trade to be Legal, Sustainable, and Disease Free.
Until recently, most conservation projects concerned with bushmeat have tended to focus on research, education, and enforcement, with few attempts to provide alternative livelihoods or food sources.
Many of the countries central to the trade are poor and suffer from corruption.
Chimpanzee
Chimpanzees carry viruses which can jump to humans
These countries need resources, incentives and training if they are to apply and enforce national and international regulations.
Prosecution of illegal traders often fail because of inadequate availability of resources to identify the type of meat concerned, so laboratories need to be set up to enable simple and inexpensive forensic services.
In importing countries, bushmeat is often not considered a high priority by customs authorities when compared with, for example, drugs or arms; so the profile of bushmeat in the international enforcement arena needs to be raised.
Extensive public awareness programmes are required, aimed at educating people at all levels of the trade.
A number of umbrella organisations have been established in recent years to try and improve local education, such as the Bushmeat-free Eastern Africa Network (BEAN) initiative. Some have been very successful.
However, far more effort is needed, with co-ordination at an international level.
Perhaps most importantly, people who currently rely on the illegal bushmeat trade for their livelihood or as an essential protein source need to be given alternative options; and herein lies arguably the greatest challenge.
Some good initiatives exist, including the development of fish farms, apiaries, and arable agriculture projects. Many more are required if the trade is to be significantly reduced.
Local actions to curb the bushmeat trade need to be resourced through global responses, requiring significant investment at a time of international financial instability and introspection.
If Africa's unique wildlife, and its rural communities, are to survive the impacts of the bushmeat trade, continued well-directed development aid for the poor countries of Africa throughout this period of global financial uncertainty is essential.
Mark Jones is programmes and fundraising director of Care for the Wild International, a UK-based conservation charity
The Green Room is a series of opinion articles on environmental topics running weekly on the BBC News website


Do you agree with Mark Jones? Are a growing number of African species facing the possibility of being eaten out of existence? Do Western nations need to do more to tackle the problem of illegal bushmeat imports? Or are there more pressing issues that are threatening global biodiversity?
I am completely agreed with Mark Jones. The bushmeat trade could eliminate all viable populations of African apes within the next 5-15 years. It is not just confined to Africa, the bushmeat trade is global phenomenon. The demand for bushmeat will continue to rise with the ever increasing populatations. Besides, people have been infected with HIV viruses from consuming primates. So, it is the time to tackle this vulnerable crisis for saving biodiversity.
Engr Salam, LGED,Bangladesh
The 'bushmeat' industry is out of hand. It also spreads to such things as unsustainable extraction of prawns from Lake St. Lucia by overseas syndicates.
Rosanne Clark, Himeville, South Africa
I quite dispute that the term "bush meat" is usually used in reference to the illegal trade of wild animals in Africa. Africa also has a significant number of game reserves to protect and serve as a sanctuary for animals in the wild. Bush meat is rather a common term amongst africans, refering to wild animals typical to some but not all those species mentioned.I would clearly attribute the phrase as wild meat specific for the purpose of consumption eg "game". However a large number are not protected species due to the fact that most of these African countries are truly faced with more pressing issues than passing legislation to protect grass cutters,antelopes including some breed of apes. Even in Africa, protection of wildlife exists prohibiting the sale and export of tigers, elephants, lions and rhino. The exploitation of these animals i have just mentioned is not neccessary for food but are widely sought for their ornamental, symbolic and medicinal value on an international large scale. we should be able to distinguish between "bush meat" and those animal species requiring protection.
Mark Adedeji, London
Yes i agree with Jones report,but what the government and the international community needs to understands is that as long as poverty keeps on increasing this hunting of endangered species will not stopt because as you already know it is a lifly hood for many families in the rural areas especially in Cameroon, Garbon, CAR, Ghana ctc. Beside that government strategy and policies to combate this activities are to weak or insufficient to meet any progress, for example in Cameroon to get a licence and to own a gun its very expensive and difficult as such the hunters or local people prefered to go underground to buy illegal guns to carry on thier illegal activities. A articipatory approach is needed were the hunters or local people are allow to take part in disscussions and meetings concerning the importance of the protection of endangered speciers and they should be given some incentives and motivation if not then give them Jobs so that they can be able to feed thier families.
Tanke Samson, Finland
A sustainable diverse ecology is of paramount importance not only for the mere survival of species but for the next generation to enjoy them as well. It is a legacy that must be preserved as a prosterity. How selfish it is to eat out animals to extintion whilst succeeding generations can only see them in photographs. The athourities should manage the life stock inventory and monitor their hunting or harvesting to curtail animal meat commercialisation.
Mr. Steven Marcial, Arima, Trinidad.
"..the trade in bushmeat, defined as meat from Africa's wild animals traded for human consumption. The term bushmeat is normally used in reference to the illegal trade." Bushmeat is simply meat from wild animals. Simples..as Aleksandr Orlov would say. The article provided a good insight and made a good read. For majority of the people though, it is still a subsistence activity.
JO, Tooting, London

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