The disease, caused by low levels of vitamin D generated in the body from sunshine and certain foods, had died out around 80 years ago but is now coming back.
Cases of rickets in children have occurred in northern England and Scotland where there are fewer months of the year with sufficient sunshine to obtain enough vitamin D but now doctors are seeing it on the South coast as well.
It is thought extensive use of sunscreen, children playing more time on computer games and TV rather than playing outside and a poor diet are to blame.
Professor Nicholas Clarke, consultant orthopaedic surgeon at Southampton General Hospital and professor of paediatric orthopaedic surgery at the University of Southampton, said: "The return of rickets in northern parts of the UK came as a surprise despite the colder climate and lower levels of sunshine in the north, but what has developed in Southampton is quite astonishing."
Children from all backgrounds are being affected now and the disease is not limited to the poor as it was in Victorian times.